Results 81 to 90 of about 3,727 (206)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Limits on Optical Counterparts to the Repeating Fast Radio Burst 20180916B from High-speed Imaging with Gemini-North/‘Alopeke

The Astrophysical Journal
We report on contemporaneous optical observations at ≈10 ms timescales from the fast radio burst (FRB) 20180916B of two repeat bursts (FRB 20201023 and FRB 20220908) taken with the ‘Alopeke camera on the Gemini-North telescope.
Charles D. Kilpatrick, Nicolas Tejos, Bridget C. Andersen, J. Xavier Prochaska, Consuelo Núñez, Emmanuel Fonseca, Zachary Hartman, Steve B. Howell, Tom Seccull, Shriharsh P. Tendulkar   +9 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The New Horizons Extended Mission Target: Arrokoth Search and Discovery

The Planetary Science Journal
Following the Pluto flyby of the New Horizons spacecraft, the mission provided a unique opportunity to explore the Kuiper Belt in situ. The possibility existed to fly by a Kuiper Belt object (KBO), as well as to observe additional objects at distances ...
Marc W. Buie, John R. Spencer, Simon B. Porter, Susan D. Benecchi, Alex H. Parker, S. Alan Stern, Michael Belton, Richard P. Binzel, David Borncamp, Francesca DeMeo, S. Fabbro, Cesar Fuentes, Hisanori Furusawa, Tetsuharu Fuse, Pamela L. Gay, Stephen Gwyn, Matthew J. Holman, H. Karoji, J. J. Kavelaars, Daisuke Kinoshita, Satoshi Miyazaki, Matt Mountain, Keith S. Noll, David J. Osip, Jean-Marc Petit, Neill I. Reid, Scott S. Sheppard, Mark Showalter, Andrew J. Steffl, Ray E. Sterner, Akito Tajitsu, David J. Tholen, David E. Trilling, Harold A. Weaver, Anne J. Verbiscer, Lawrence H. Wasserman, Takuji Yamashita, Toshifumi Yanagisawa, Fumi Yoshida, Amanda M. Zangari   +39 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Constraining Near-simultaneous Radio Emission from Short Gamma-Ray Bursts Using CHIME/FRB

The Astrophysical Journal
We use the Canadian Hydrogen Intensity Mapping Experiment (CHIME) Fast Radio Burst (FRB) Project to search for FRBs that are temporally and spatially coincident with gamma-ray bursts (GRBs) occurring between 2018 July 7 and 2023 August 3.
Alice P. Curtin, Sloane Sirota, Victoria M. Kaspi, Shriharsh P. Tendulkar, Mohit Bhardwaj, Amanda M. Cook, Wen-Fai Fong, B. M. Gaensler, Robert A. Main, Kiyoshi W. Masui, Daniele Michilli, Ayush Pandhi, Aaron B. Pearlman, Paul Scholz, Kaitlyn Shin   +14 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Planet Masses, Radii, and Orbits from NASA’s K2 Mission

The Astrophysical Journal Supplement Series
We report the masses, sizes, and orbital properties of 86 planets orbiting 55 stars observed by NASA’s K2 Mission with follow-up Doppler measurements by the HIRES spectrometer at the W. M.
Andrew W. Howard, Evan Sinukoff, Sarah Blunt, Erik A. Petigura, Ian J. M. Crossfield, Howard Isaacson, Molly Kosiarek, Ryan A. Rubenzahl, John M. Brewer, Benjamin J. Fulton, Courtney D. Dressing, Lea A. Hirsch, Heather Knutson, John H. Livingston, Sean M. Mills, Arpita Roy, Lauren M. Weiss, Bjorn Benneke, David R. Ciardi, Jessie L. Christiansen, William D. Cochran, Justin R. Crepp, Erica Gonzales, Brad M. S. Hansen, Kevin Hardegree-Ullman, Steve B. Howell, Sébastien Lépine, Arturo O. Martinez, Leslie A. Rogers, Joshua E. Schlieder, Michael Werner, Alex S. Polanski, Isabel Angelo, Corey Beard, Aida Behmard, Luke G. Bouma, Casey L. Brinkman, Ashley Chontos, Fei Dai, Paul A. Dalba, Steven Giacalone, Samuel K. Grunblatt, Michelle L. Hill, Stephen R. Kane, Jack Lubin, Andrew W. Mayo, Teo Mocnik, Joseph M. Akana Murphy, Malena Rice, Lee J. Rosenthal, Dakotah Tyler, Judah Van Zandt, Samuel W. Yee   +52 more
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source