Results 51 to 60 of about 6,477,198 (276)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Evidence for life in the isotopic analysis of surface sulphates in the Haughton impact structure, and potential applications on Mars [PDF]

, 2012
The analysis of sulphur isotopic compositions in three sets of surface sulphate samples from the soil zone in the Haughton impact structure shows that they are distinct.
Izawa, M.R.M., Osinski, G.R., Boyce, A.J., Banerjee, N., Lee, P., Parnell, J., Flemming, R., Matthew, R.M.   +7 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment

Frontiers in Physiology, 2019
Confinement experiments are essential to prepare long-term space exploration. The 180-day Chinese CELSS (Controlled Ecological Life Support System) study is unique in its design, including a closed-loop system and mid-mission simulation of Mars-like day ...
Ming Yuan, Ming Yuan, Marc-Antoine Custaud, Marc-Antoine Custaud, Zi Xu, Jingyu Wang, Min Yuan, Carole Tafforin, Loïc Treffel, Loïc Treffel, Philippe Arbeille, Michel Nicolas, Claude Gharib, Guillemette Gauquelin-Koch, Laurent Arnaud, Jean-Christophe Lloret, Yinghui Li, Nastassia Navasiolava   +17 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Close - up imaging of Oxia Planum analogue samples under different illumination conditions: preparing for the ExoMars rover mission

Frontiers in Astronomy and Space Sciences
ExoMars is an astrobiology program led by the European Space Agency, which foresees the launch of a rover that will look for signs of past life on Mars.
Gabriela Ligeza, Tomaso R. R. Bontognali, Tomaso R. R. Bontognali, Lucile Fayon, Axel Bouquety, Beda Hofmann, Beda Hofmann, Jean-Luc Josset, Nikolaus J. Kuhn   +8 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Careers in Bioethics

Voices in Bioethics, 2018
Paul Root Wolpe is a bioethicist with sprawling interests. He is currently the Raymond F. Schinazi Distinguished Research Chair in Jewish Bioethics at Emory University, and his biography there lists over a dozen areas of expertise ranging from Death and ...
John Zaikowski
doaj   +1 more source