Results 51 to 60 of about 6,505,885 (276)

Evidence for life in the isotopic analysis of surface sulphates in the Haughton impact structure, and potential applications on Mars [PDF]

, 2012
The analysis of sulphur isotopic compositions in three sets of surface sulphate samples from the soil zone in the Haughton impact structure shows that they are distinct.
Izawa, M.R.M., Osinski, G.R., Boyce, A.J., Banerjee, N., Lee, P., Parnell, J., Flemming, R., Matthew, R.M.   +7 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment

Frontiers in Physiology, 2019
Confinement experiments are essential to prepare long-term space exploration. The 180-day Chinese CELSS (Controlled Ecological Life Support System) study is unique in its design, including a closed-loop system and mid-mission simulation of Mars-like day ...
Ming Yuan, Ming Yuan, Marc-Antoine Custaud, Marc-Antoine Custaud, Zi Xu, Jingyu Wang, Min Yuan, Carole Tafforin, Loïc Treffel, Loïc Treffel, Philippe Arbeille, Michel Nicolas, Claude Gharib, Guillemette Gauquelin-Koch, Laurent Arnaud, Jean-Christophe Lloret, Yinghui Li, Nastassia Navasiolava   +17 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Close - up imaging of Oxia Planum analogue samples under different illumination conditions: preparing for the ExoMars rover mission

Frontiers in Astronomy and Space Sciences
ExoMars is an astrobiology program led by the European Space Agency, which foresees the launch of a rover that will look for signs of past life on Mars.
Gabriela Ligeza, Tomaso R. R. Bontognali, Tomaso R. R. Bontognali, Lucile Fayon, Axel Bouquety, Beda Hofmann, Beda Hofmann, Jean-Luc Josset, Nikolaus J. Kuhn   +8 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Careers in Bioethics

Voices in Bioethics, 2018
Paul Root Wolpe is a bioethicist with sprawling interests. He is currently the Raymond F. Schinazi Distinguished Research Chair in Jewish Bioethics at Emory University, and his biography there lists over a dozen areas of expertise ranging from Death and ...
John Zaikowski
doaj   +1 more source