Results 91 to 100 of about 6,669,251 (236)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Long-Range Rovers for Mars Exploration and Sample Return

, 2001
This paper discusses long-range rovers to be flown as part of NASA’s newly reformulated Mars Exploration Program (MEP).
Joe C. Parrish
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Limits on Optical Counterparts to the Repeating Fast Radio Burst 20180916B from High-speed Imaging with Gemini-North/‘Alopeke

The Astrophysical Journal
We report on contemporaneous optical observations at ≈10 ms timescales from the fast radio burst (FRB) 20180916B of two repeat bursts (FRB 20201023 and FRB 20220908) taken with the ‘Alopeke camera on the Gemini-North telescope.
Charles D. Kilpatrick, Nicolas Tejos, Bridget C. Andersen, J. Xavier Prochaska, Consuelo Núñez, Emmanuel Fonseca, Zachary Hartman, Steve B. Howell, Tom Seccull, Shriharsh P. Tendulkar   +9 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Astrobiology and the Human Exploration of Mars [PDF]

, 2010
In March 2007, the Mars Exploration Program Analysis Group (MEPAG) chartered the Human Exploration of Mars Science Analysis Group (HEM-SAG), co-chaired by J. B. Garvin and J. S. Levine and consisting of about 30 Mars scientists from the U.S.
Garvin, James B., Beaty, David, Drake, B. G., Levine, Joel S.   +3 more
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

The New Horizons Extended Mission Target: Arrokoth Search and Discovery

The Planetary Science Journal
Following the Pluto flyby of the New Horizons spacecraft, the mission provided a unique opportunity to explore the Kuiper Belt in situ. The possibility existed to fly by a Kuiper Belt object (KBO), as well as to observe additional objects at distances ...
Marc W. Buie, John R. Spencer, Simon B. Porter, Susan D. Benecchi, Alex H. Parker, S. Alan Stern, Michael Belton, Richard P. Binzel, David Borncamp, Francesca DeMeo, S. Fabbro, Cesar Fuentes, Hisanori Furusawa, Tetsuharu Fuse, Pamela L. Gay, Stephen Gwyn, Matthew J. Holman, H. Karoji, J. J. Kavelaars, Daisuke Kinoshita, Satoshi Miyazaki, Matt Mountain, Keith S. Noll, David J. Osip, Jean-Marc Petit, Neill I. Reid, Scott S. Sheppard, Mark Showalter, Andrew J. Steffl, Ray E. Sterner, Akito Tajitsu, David J. Tholen, David E. Trilling, Harold A. Weaver, Anne J. Verbiscer, Lawrence H. Wasserman, Takuji Yamashita, Toshifumi Yanagisawa, Fumi Yoshida, Amanda M. Zangari   +39 more
doaj   +1 more source