Results 181 to 190 of about 6,787,265 (281)

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Cardiovascular risks and hazards associated with deep space exploration. [PDF]

Commun Med (Lond)
Brojakowska A, Bisserier M, Eskandari A, Jagana V, Khlgatian MK, Arakelyan A, Fogarty J, Kovacic JC, Goukassian DA.   +8 more
europepmc   +1 more source

PCGF1 Promotes the Tumorigenesis of Malignancies Through Upregulating CCDC34 in Glioma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Polycomb group factor 1 (PCGF1) and coiled‐coil domain‐containing protein 34 (CCDC34) have been implicated in tumorigenesis in multiple malignancies. However, their biological functions and prognostic significance in glioma remain poorly defined.
Yuanbing Chen, Jianbing Xiong, Ziran Ou, Tianhao Zhao, Hui Li, Jun Huang, Zhi Tian, Wuyang Cao   +7 more
wiley   +1 more source

Performance Evaluation, Optical Optimization and Earth-Based Validation of Star Sensors for Ground Detection in Martian Dust Environments. [PDF]

Sensors (Basel)
Gao Y, He MJ, Li Y, Wang HY, Li SL, Qi H.   +5 more
europepmc   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Spatially distributed complex organic matter detected in an ancient river valley in Jezero crater, Mars. [PDF]

Sci Adv
Murphy AE, Uckert K, Hand KP, Bhartia R, Bykov SV, Hickman-Lewis K, Jakubek RS, Lee C, McCubbin FM, Minitti ME, Pascuzzo A, Siljeström S, Sharma S, Steele A, Williford KH, Abbey W, Asher SA, Barnes R, Barr PA, Bell JF, Beyssac O, Bosak T, Bramble MS, Brown A, Broz AP, Buckner D, Cardarelli EL, Carsten JL, Corpolongo A, Czaja A, Edgington SGC, Ehlmann BL, Farley KA, Fornaro T, Fries M, González-Burgos R, Gupta S, Haney NC, Hug W, Huggett J, Hurowitz JA, Imbeah S, Clark J, Jones AJ, Kah LC, Kennedy MR, Lee SW, Maki J, Nixon B, Núñez JI, Osterhout JT, Phelan ND, Phua YY, Ravine MA, Hollis JR, Scheller E, Schulte MD, Sephton MA, Simon JI, Srivastava A, Stack KM, Van Beek J, Weiss BP, Wiens R, Williams AJ, Wogsland BV, Yingst RA.   +66 more
europepmc   +1 more source

Disentangling the Genetic Relationship Between Sleep and Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A bidirectional relationship between sleep and epilepsy is well recognised, yet the biological mechanisms linking them remain poorly understood. Both have a genetic basis, with genome‐wide association studies (GWAS) capturing polygenic contributions.
Khang N. Le, Victoria E. Jackson, Rachel E. Stirling, Zachary F. Gerring, Remi Stevelink, Samuel F. Berkovic, Ingrid E. Scheffer, Philippa J. Karoly, Melanie Bahlo, Karen L. Oliver   +9 more
wiley   +1 more source

Mass-independent oxygen isotope fractionation driven by energetic-particle irradiation of icy solids. [PDF]

Proc Natl Acad Sci U S A
Dominguez G, Caplan C, Tafla L, Lucas J, Liu MC, McKeegan K, Gillis J.   +6 more
europepmc   +1 more source

Four‐Year Cognitive Outcomes in Multiple Sclerosis: Associations With Lesion Myelin Integrity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Cognitive impairment is prevalent in patients with multiple sclerosis (MS) but whether lesion myelin integrity influences future cognitive outcomes remains unclear. We investigated the relationship between baseline lesion myelin water fraction (MWF) and cognitive performance 4 years later.
Iliana Pliska‐Bloch, Hannah Schwartz, Kimberly H. Markowitz, Abhishek Jaywant, Christopher D. Hildenbrand, Jai Perumal, Ulrike W. Kaunzner, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Future Model for Efficient and Advanced Space Transportation: Exploration and Perspectives. [PDF]

Research (Wash D C)
Chen H, Wang X, Song Z, Li D, Bao W.
europepmc   +1 more source