Results 101 to 110 of about 6,477,198 (276)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Mars Exploration Rovers: 4 Years on Mars [PDF]

, 2008
This January, the Mars Exploration Rovers "Spirit" and "Opportunity" are starting their fifth year of exploring the surface of Mars, well over ten times their nominal 90-day design lifetime.
Landis, Geoffrey A.
core  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Perspectives for Crewed Missions to Mars: Exploration from Orbit and/or Short Stay

The debate “humans versus robots”, on Mars or anywhere else will not be engaged here. The decision has been made—by a single entity, a coalition, or a wide international agreement—to send astronauts to Mars.
Puumala, Mikko, de Vera, Jean Pierre Paul, Sivula, Oskari, Kereszturi, Akos, Milligan, Tony, Ewald, Reinhold, Mason, Nigel, Javaux, Emmanuelle J., Possnig, Carmen, Viso, Michel, Chatzitheodoridis, Elias, Lee, Natuschka M.,, Siljeström, Sandra, De Vera, Jean-Pierre, Javaux, Emmanuelle, Arnould, Jacques, Holynska, Malgorzata, Detrell, Gisela, Freissinet, Caroline, Vago, Jorge L., Mason, N. J., Lehto, Kirsi, Lee, Natuschka M., Lee, Natuschka   +23 more
core   +1 more source

The New Horizons Extended Mission Target: Arrokoth Search and Discovery

The Planetary Science Journal
Following the Pluto flyby of the New Horizons spacecraft, the mission provided a unique opportunity to explore the Kuiper Belt in situ. The possibility existed to fly by a Kuiper Belt object (KBO), as well as to observe additional objects at distances ...
Marc W. Buie, John R. Spencer, Simon B. Porter, Susan D. Benecchi, Alex H. Parker, S. Alan Stern, Michael Belton, Richard P. Binzel, David Borncamp, Francesca DeMeo, S. Fabbro, Cesar Fuentes, Hisanori Furusawa, Tetsuharu Fuse, Pamela L. Gay, Stephen Gwyn, Matthew J. Holman, H. Karoji, J. J. Kavelaars, Daisuke Kinoshita, Satoshi Miyazaki, Matt Mountain, Keith S. Noll, David J. Osip, Jean-Marc Petit, Neill I. Reid, Scott S. Sheppard, Mark Showalter, Andrew J. Steffl, Ray E. Sterner, Akito Tajitsu, David J. Tholen, David E. Trilling, Harold A. Weaver, Anne J. Verbiscer, Lawrence H. Wasserman, Takuji Yamashita, Toshifumi Yanagisawa, Fumi Yoshida, Amanda M. Zangari   +39 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Constraining Near-simultaneous Radio Emission from Short Gamma-Ray Bursts Using CHIME/FRB

The Astrophysical Journal
We use the Canadian Hydrogen Intensity Mapping Experiment (CHIME) Fast Radio Burst (FRB) Project to search for FRBs that are temporally and spatially coincident with gamma-ray bursts (GRBs) occurring between 2018 July 7 and 2023 August 3.
Alice P. Curtin, Sloane Sirota, Victoria M. Kaspi, Shriharsh P. Tendulkar, Mohit Bhardwaj, Amanda M. Cook, Wen-Fai Fong, B. M. Gaensler, Robert A. Main, Kiyoshi W. Masui, Daniele Michilli, Ayush Pandhi, Aaron B. Pearlman, Paul Scholz, Kaitlyn Shin   +14 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Planet Masses, Radii, and Orbits from NASA’s K2 Mission

The Astrophysical Journal Supplement Series
We report the masses, sizes, and orbital properties of 86 planets orbiting 55 stars observed by NASA’s K2 Mission with follow-up Doppler measurements by the HIRES spectrometer at the W. M.
Andrew W. Howard, Evan Sinukoff, Sarah Blunt, Erik A. Petigura, Ian J. M. Crossfield, Howard Isaacson, Molly Kosiarek, Ryan A. Rubenzahl, John M. Brewer, Benjamin J. Fulton, Courtney D. Dressing, Lea A. Hirsch, Heather Knutson, John H. Livingston, Sean M. Mills, Arpita Roy, Lauren M. Weiss, Bjorn Benneke, David R. Ciardi, Jessie L. Christiansen, William D. Cochran, Justin R. Crepp, Erica Gonzales, Brad M. S. Hansen, Kevin Hardegree-Ullman, Steve B. Howell, Sébastien Lépine, Arturo O. Martinez, Leslie A. Rogers, Joshua E. Schlieder, Michael Werner, Alex S. Polanski, Isabel Angelo, Corey Beard, Aida Behmard, Luke G. Bouma, Casey L. Brinkman, Ashley Chontos, Fei Dai, Paul A. Dalba, Steven Giacalone, Samuel K. Grunblatt, Michelle L. Hill, Stephen R. Kane, Jack Lubin, Andrew W. Mayo, Teo Mocnik, Joseph M. Akana Murphy, Malena Rice, Lee J. Rosenthal, Dakotah Tyler, Judah Van Zandt, Samuel W. Yee   +52 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source