Results 81 to 90 of about 6,477,182 (276)
Calibrating mars orbiter laser altimeter pulse widths at mars science laboratory candidate landing sites [PDF]
, 2014 Accurate estimates of surface roughness allow quantitative comparisons between planetary terrains. These comparisons enable us to improve our understanding of commonly occurring surface processes, and develop a more complete analysis of candidate landing
Muller, J.-P. +6 more
core +1 more source
Low-cost, multi-agent systems for planetary surface exploration [PDF]
, 2012 The use of off-the-shelf consumer electronics combined with top-down design methodologies have made small and inexpensive satellites, such as CubeSats, emerge as viable, low-cost and attractive space-based platforms that enable a range of new and ...
Punzo, Giuliano +4 more
core +3 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Mars Exploration Program and Mars Technology Program
, 2002 The Mars Exploration Program and constituent Mars Technology Program are described. Current, ongoing and future NASA-led missions are presented, including discussions of scientific accomplishments and objectives as well as technology validations ...
Whetsel, Charles W.
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Erosion rate and previous extent of interior layered deposits on Mars revealed by obstructed landslides [PDF]
, 2014 We describe interior layered deposits on Mars that have obstructed landslides before undergoing retreat by as much as 2 km. These landslides differ from typical Martian examples in that their toe height increases by as much as 500 m in a distinctive ...
Warner, N.H., Grindrod, Peter M.
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Lunar base agent-based modeling - A benchmark for simulating crewed space missions.
PLoS ONESpace exploration has progressed significantly since the mid-20th century, and recent technological advancements, along with the emergence of commercial space travel, have led to substantial leaps in planning for future space missions.
Raymond Vera +2 more
doaj +1 more source