Results 111 to 120 of about 3,690 (206)

Toward "Safe" Chemicals and Materials on Mars: Knowledge Gaps for Expanding Planetary Protection Requirements. [PDF]

Environ Sci Technol
Hader JD, Fairén AG, Ågerstrand M, MacLeod M, Nowack B.   +4 more
europepmc   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Cardiovascular risks and hazards associated with deep space exploration. [PDF]

Commun Med (Lond)
Brojakowska A, Bisserier M, Eskandari A, Jagana V, Khlgatian MK, Arakelyan A, Fogarty J, Kovacic JC, Goukassian DA.   +8 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Spatially distributed complex organic matter detected in an ancient river valley in Jezero crater, Mars. [PDF]

Sci Adv
Murphy AE, Uckert K, Hand KP, Bhartia R, Bykov SV, Hickman-Lewis K, Jakubek RS, Lee C, McCubbin FM, Minitti ME, Pascuzzo A, Siljeström S, Sharma S, Steele A, Williford KH, Abbey W, Asher SA, Barnes R, Barr PA, Bell JF, Beyssac O, Bosak T, Bramble MS, Brown A, Broz AP, Buckner D, Cardarelli EL, Carsten JL, Corpolongo A, Czaja A, Edgington SGC, Ehlmann BL, Farley KA, Fornaro T, Fries M, González-Burgos R, Gupta S, Haney NC, Hug W, Huggett J, Hurowitz JA, Imbeah S, Clark J, Jones AJ, Kah LC, Kennedy MR, Lee SW, Maki J, Nixon B, Núñez JI, Osterhout JT, Phelan ND, Phua YY, Ravine MA, Hollis JR, Scheller E, Schulte MD, Sephton MA, Simon JI, Srivastava A, Stack KM, Van Beek J, Weiss BP, Wiens R, Williams AJ, Wogsland BV, Yingst RA.   +66 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment. [PDF]

Nanomicro Lett
Jiang Q, Wang B, Cheng Y, Wang Y, Zhao H, Lu Y.   +5 more
europepmc   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Diverse organic molecules on Mars revealed by the first SAM TMAH experiment. [PDF]

Nat Commun
Williams AJ, Eigenbrode JL, Millan M, Williams RH, Mcintosh OM, Teinturier S, Roach J, Malespin C, McAdam AC, Mahaffy P, Bryk AB, Buch A, Boulesteix D, Chou L, Dworkin JP, Fox V, Franz HB, Freissinet C, Glavin DP, House CH, Johnson SS, Lewis JMT, Mojarro A, Navarro-Gonzalez R, Pozarycki C, Steele A, Summons RE, Szopa C, Thorpe MT, Vasavada AR.   +29 more
europepmc   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source