Results 221 to 230 of about 1,106,622 (296)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Is socioeconomic position associated with hospital admissions? findings from a population-based cross-sectional study among middle-aged and older Malaysians. [PDF]

BMJ Open
Jawahir S, Balqis NZ, Lee SWH, Saw PS, Kharie MF, Fun WH, Apalasamy YD, Mansor N, Awang H.   +8 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Hardware-independent control for partial gravity simulation using a 2-DOF robotic device. [PDF]

Sci Rep
Kim YJ, Park S, Kim S.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Early laboratory-based differentiation of severe influenza pneumonia and influenza-associated encephalopathy in children using a multi-model, stability-aware machine-learning workflow: a single-center retrospective cohort study. [PDF]

BMC Infect Dis
Yan Y, Li X, Li X, Kuang L, Guo M, Xu T, Hua L, Wang C, Zhu B.   +8 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Telerehabilitation Following Stroke: Development of Training Content and Evaluation of an App-Based Training Program. [PDF]

JMIR Rehabil Assist Technol
Ziller C, Gäumann S, Lüscher S, Paulissen N, Behrendt F, Suica Z, Crüts B, Gamerschlag L, Parmar K, Gerth HU, Bonati LH, Schuster-Amft C.   +11 more
europepmc   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Carbon monoxide dehydrogenase-encoding microorganisms in volcanic astrobiological analogues: an enzyme system to investigate the evolution of life. [PDF]

FEMS Microbiol Ecol
Latorre V, Vázquez-Campos X, Ferrari B, Hernández M.   +3 more
europepmc   +1 more source