Results 11 to 20 of about 722 (110)

Extension of the viral ecology in humans using viral profile hidden Markov models. [PDF]

PLoS ONE, 2018
When human samples are sequenced, many assembled contigs are "unknown", as conventional alignments find no similarity to known sequences. Hidden Markov models (HMM) exploit the positions of specific nucleotides in protein-encoding codons in various ...
Zurab Bzhalava, Emilie Hultin, Joakim Dillner   +2 more
doaj   +2 more sources

Virus Genomes from Deep Sea Sediments Expand the Ocean Megavirome and Support Independent Origins of Viral Gigantism [PDF]

mBio, 2019
The nucleocytoplasmic large DNA viruses (NCLDV) of eukaryotes (proposed order, “Megavirales”) include the families Poxviridae, Asfarviridae, Iridoviridae, Ascoviridae, Phycodnaviridae, Marseilleviridae, and Mimiviridae, as well as still unclassified ...
Disa Bäckström, Natalya Yutin, Steffen L. Jørgensen, Jennah Dharamshi, Felix Homa, Katarzyna Zaremba-Niedwiedzka, Anja Spang, Yuri I. Wolf, Eugene V. Koonin, Thijs J. G. Ettema   +9 more
doaj   +2 more sources

Presence of CRISPR CAS-Like Sequences as a Proposed Mechanism for Horizontal Genetic Exchanges between Trichomonas vaginalis and Its Associated Virus: A Comparative Genomic Analysis with the First Report of a Putative CRISPR CAS Structures in Eukaryotic Cells. [PDF]

Biomed Res Int, 2023
Introduction. Trichomonas vaginalis genome is among the largest genome size and coding capacities. Combinations of gene duplications, transposon, repeated sequences, and lateral gene transfers (LGTs) have contributed to the unexpected large genomic size and diversity. This study is aimed at investigating genomic exchange and seeking for presence of the
Kenarkoohi A, Abdoli A, Rostamzad A, Rashnavadi M, Naserifar R, Abdi J, Shams M, Bozorgomid A, Saeb S, Al-Fahad D, Khezri K, Falahi S.   +11 more
europepmc   +2 more sources

The genomic and phylogenetic analysis of <i>Marseillevirus cajuinensis</i> raises questions about the evolution of Marseilleviridae lineages and their taxonomical organization. [PDF]

J Virol
International audienceABSTRACT Marseilleviruses (MsV) are a group of viruses that compose the Marseilleviridae family within the Nucleocytoviricota phylum. They have been found in different samples, mainly in freshwater.
de Azevedo BL, Queiroz VF, de Aquino ILM, Machado TB, de Assis FL, Reis E, Araújo Júnior JP, Ullmann LS, Colson P, Greub G, Aylward F, Rodrigues RAL, Abrahão JS.   +12 more
europepmc   +2 more sources

A rapid genome‐wide analysis of isolated giant viruses using MinION sequencing

Environmental Microbiology, Volume 25, Issue 11, Page 2621-2635, November 2023., 2023
We evaluated performance of MinION sequencing for giant virus genomics. Re‐sequencing of a prototype marseillevirus by MinION alone provided high‐quality genomes. As a proof of concept, we sequenced genomes of newly isolated giant viruses. Collectively, we concluded that MinION sequencing is an effective approach to rapidly perform a genome‐wide ...
Hiroyuki Hikida, Yusuke Okazaki, Ruixuan Zhang, Thi Tuyen Nguyen, Hiroyuki Ogata   +4 more
wiley   +1 more source

Kinetic Analysis of Acanthamoeba castellanii Infected with Giant Viruses Quantitatively Revealed Process of Morphological and Behavioral Changes in Host Cells

Microbiology Spectrum, 2021
Most virus-infected cells show morphological and behavioral changes, which are called cytopathic effects. Acanthamoeba castellanii, an abundant, free-living protozoan, serves as a laboratory host for some viruses of the phylum Nucleocytoviricota—the ...
Sho Fukaya, Masaharu Takemura
doaj   +1 more source

Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors

Traffic, Volume 23, Issue 8, Page 414-425, August 2022., 2022
Giant viruses enter their eukaryotic host cells by phagocytosis. For reproduction, they hijack the host cell's membranes by an unknown mechanism. Here, we found that giant viruses express several core factors of the eukaryotic vesicle fusion machinery, including SNARE, Rab, SM proteins, and the disassembly protein NSF.
Dany Khalifeh, Emilie Neveu, Dirk Fasshauer   +2 more
wiley   +1 more source

Comparative Analysis of the Circular and Highly Asymmetrical Marseilleviridae Genomes

Viruses, 2020
Marseilleviridae members are large dsDNA viruses with icosahedral particles 250 nm in diameter infecting Acanthamoeba. Their 340 to 390 kb genomes encode 450 to 550 protein-coding genes. Since the discovery of marseillevirus (the prototype of the family)
Léo Blanca, Eugène Christo-Foroux, Sofia Rigou, Matthieu Legendre   +3 more
doaj   +1 more source

Diversity of Amoeba-Associated Giant Viruses Isolated in Algeria

Diversity, 2020
The discovery of several giant amoeba viruses has opened up a novel area in the field of virology. Despite this, knowledge about ecology of these viruses remains patchy. In this study, we aimed to characterize the diversity of giant viruses in Algeria by
Hadjer Boudjemaa, Julien Andreani, Idir Bitam, Bernard La Scola   +3 more
doaj   +1 more source

Marseillevirus G648 ORFs

, 2022
A giant virus genome is densely packaged by stable nucleosomes within virions.The two doublet histones of Marseillevirus are distantly related to the four eukaryotic core histones and wrap 121 basepairs of DNA to form remarkably similar nucleosomes.
Henikoff, S (via Mendeley Data)
core   +1 more source