Results 121 to 130 of about 14,036 (215)
Epilepsia, EarlyView.Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden +5 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva +29 more
wiley +1 more source
European Eating Disorders Review, EarlyView.ABSTRACT Background Carers are essential in their young person's recovery during transition from child to adult eating disorder services. Despite recommendations, carer's own needs can be overlooked in transition planning. Subsequently, carers experience distress in supporting their young person and navigating the transition.
Isabel Lenham +13 more
wiley +1 more source
ON A CONJECTURE OF MARSHALL HALL [PDF]
Proceedings of the National Academy of Sciences, 1966 openaire +2 more sources
Fire and Rescue Service Preparedness for Natural Hazards
Fire and Materials, EarlyView.ABSTRACT Natural hazards driven by extreme weather events are expected to continue to pose a significant risk to citizens, property and the environment. Based on a series of national and international interviews with the Fire and Rescue Service (FRS), this paper presents an analysis of present practices within the FRS and FRS willingness to employ a ...
Johan Björck, Margaret McNamee
wiley +1 more source
Food Chemistry International, EarlyView.Scientific analysis of Anchomanes difformis roots confirms significant nutraceutical potential, containing high levels of carbohydrates, proteins, and essential minerals. Phytochemical screening revealed antioxidants such as phenols and flavonoids, and although the extracts effectively lowered plasma glucose, safety testing showed dose‐dependent risks.
Lawrence Folorunso Dada +2 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective Ovarian cancer is the deadliest gynecological cancer in the developed world. The absence of screening for early detection of ovarian cancer and the non‐specific symptoms associated with the disease mean that timely diagnosis is difficult.
Chiara Gottheil +4 more
wiley +1 more source
Integrative Conservation, EarlyView.Through systematic price collection and correction for underreporting and undetected seizures, the global illegal wildlife trade (IWT) is estimated at US$28.4–39.5 billion per year. This finding highlights that previous valuations were underestimates.
Jia Hao Tow, L. Roman Carrasco
wiley +1 more source
Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance
Interdisciplinary Medicine, EarlyView.This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang +14 more
wiley +1 more source
Irrigation and Drainage, EarlyView.ABSTRACT Climate change is making water availability more uncertain, with growing consequences for the productivity and long‐term sustainability of tropical and subtropical fruit orchards. Mangifera indica L. and Persea americana Mill. both require large amounts of water to sustain growth and productivity.
Eleonora Cataldo
wiley +1 more source