Results 71 to 80 of about 3,361 (240)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Vulnerable masculinities: Implications of gender socialisation in three rural Swazi primary schools
South African Journal of Childhood Education, 2019 Background: This article draws on social constructionism to explore vulnerable boys’ constructions of gender within three primary schools in Swaziland.
Ncamsile D. Motsa, Pholoho J. Morojele
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Loss of Masculinity as a Face of Masculinity Crises Experienced as a Result of Migration
Journal of Economy Culture and Society, 2019 The debates on migration and gender in social sciences are a growing field. In recent years, the relations between migration and masculinities have come to the fore in these debates when the field of critical studies on men and masculinities had begun to
Mehmet Bozok
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Transitory masculinities in the context of being sick with prostate cancer
Revista Latino-Americana de Enfermagem, 2019 Objective: to interpret the meanings attributed by men with prostate cancer to the experience regarding their bodies and masculinities during illness. Method: ethnographic research with 17 men, guided by the narrative method and theoretical framework of
Jeferson Santos Araújo +2 more
doaj +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
On_CultureThe (In)Visible Man film is an artistic extension of my ongoing doctoral project: “Submission Is Power: Remasculinization in Contemporary Asian American Literature.” Through a blend of abstract dance and fragmented diaristic dialogues, the film explores
Nhi Thao Do
doaj +1 more source
Reconstituting Ndembu traditional eco-masculinities: An African theodecolonial perspective
Verbum et Ecclesia, 2016 This article engages with the notion of Ndembu traditional eco-masculinities which was conceptualised in a framework of sacrifice as ground for manliness.
Chammah J. Kaunda
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source