Results 81 to 90 of about 832,334 (361)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Semiotika (Vilniaus universitetas), 2021 This article presents the semiotic analysis of Giedrė Kazlauskaitė poem Venecijietiška kaukė… The research aims to delve into the structures of the poetic world of Giedrė Kazlauskaitė, which is achieved through executing a detailed semiotic analysis of ...
Karolina Sadauskaitė-Varnelė
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Les cornes, la croix et les défenses
Afrique Archéologie Arts, 2011 This paper is based on the study of three masks collected by C. Lemaire mission in the area of Lake Moero in the 1890s. The author attemps to understand the origin and the function of these objects which relate to a little-known facet of the arts in ...
Julien Volper
doaj +1 more source
The impact of face masks on spectral acoustics of speech: Effect of clear and loud speech styles [PDF]
, 2022 Thea Knowles, Gursharan Badh
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Sensing property of piezoelectric filter material and its application in masks
Meitan xuebaoIn the field of labor protection, the real-time monitoring of workers’ physical health status has received a lot of attention. Because breathing contains a lot of physiological information, the development of wearable devices with sensing functions for ...
Chen WANG +3 more
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Knowledge, attitude and practice of dentists in Coronavirus disease 2019 pandemic in Turkey
European Oral Research, 2020 Purpose The aim was to assess the knowledge, attitudes and anxiety of the dentists in relation to COVID-19. Materials and Methods This cross-sectional survey was conducted amongst 590 dentists employed in Turkey from March to April 2020.
Berkay Tokuç, Fatih Mehmet Coşkunses
doaj +1 more source