Results 271 to 280 of about 56,945 (299)

EuroSCORE II: Current limitations and physiological gaps in risk stratification

Experimental Physiology, EarlyView.
Abstract Risk stratification remains critical in cardiac surgery, enabling clinicians to predict adverse outcomes and guide perioperative management. The European System for Cardiac Operative Risk Evaluation (EuroSCORE) II, introduced in 2011, incorporates 18 key variables to provide an evidence‐based approach to risk assessment.
Jing Yong Ng, Eu Fon Tan, Marsioleda Kemberi, Eduardo Urgesi, Matti Jubouri, Damian M. Bailey, Mohamad Bashir, Wael I. Awad   +7 more
wiley   +1 more source

Evaluation of an enhanced viscosity artificial tear for moderate to severe dry eye disease: A multicenter, double-masked, randomized 30-day study [PDF]

, 2019
Berdy, Gregg, Carlisle-Wilcox, Cindy, Douglass, David, Haque, Sameena, Lievens, Christopher, Lin, Hugh, Montaquila, Stephen, Simmons, Peter, Vehige, Joseph   +8 more
core   +1 more source

The impact of healthy motion seating on lower‐limb blood flow and blood pressure response to simulated long‐haul air travel

Experimental Physiology, EarlyView.
Abstract Prolonged sitting inherent to long‐haul air travel can acutely decrease lower‐limb blood flow and increase brachial blood pressure. Healthy motion seating (HMS), which passively alters sitting interface pressure and posture, is a promising technology which may attenuate the deleterious effects of long‐haul air travel. The aim of this study was
Jane Lewis, Barry J. Mcdonnell, Mark Butlin, Edward Johnston, Amira Tairi, Thomas Griffiths, Gisele Bentley, Peter Sykes, Keeron Stone   +8 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Effect of moderate altitude and nocturnal oxygen therapy on cerebrovascular function in patients with COPD: A randomized, crossover trial at 2048 m

Experimental Physiology, EarlyView.
Abstract We investigated whether nocturnal oxygen therapy improves next‐day cerebrovascular function in lowlanders with chronic obstructive pulmonary disease (COPD) staying at moderate altitude. This randomized, placebo‐controlled single‐blind crossover trial was performed in moderate‐to‐severe COPD patients [forced expiratory volume in 1 s (FEV1 ...
Dominic Gilliand, Tsogyal D. Latshang, Sayaka S. Aeschbacher, Fabienne Huber, Deborah Flueck, Mona Lichtblau, Stefanie Ulrich, Elisabeth D. Hasler, Philipp M. Scheiwiller, Julian Müller, Silvia Ulrich, Konrad E. Bloch, Michael Furian   +12 more
wiley   +1 more source

Whole‐body hot water immersion effect on cerebral haemodynamics and subsequent cerebrovascular reactivity to carbon dioxide

Experimental Physiology, EarlyView.
Abstract To test the hypothesis that hot water immersion (HWI) improves cerebrovascular function via shear‐mediated mechanisms, this study determined cerebrovascular reactivity to carbon dioxide (CVRCO2${\mathrm{CV}}{{\mathrm{R}}_{{\mathrm{C}}{{\mathrm{O}}_2}}}$) before and after 60 min of 39°C HWI and a 21°C air control (CON) in 15 healthy ...
Samuel F. Leaney, Ester Tommasini, Guto W. Hughes, Alison M. Shepherd, Nyah D. Kingdon, Justin S. Lawley, Geoff B. Coombs, Jonathan P. Moore, Samuel J. Oliver   +8 more
wiley   +1 more source

How do physiological networks respond to normobaric hypoxia and isometric exercise?

Experimental Physiology, EarlyView.
Abstract The dynamics of physiological systems are impacted by both exercise and hypoxia. Network models can be used to map the interactions between various physiological components in environmental physiology and exercise using the concepts of information theory.
Danilo Bondi, Cecilia Morandotti, Salvatore Annarumma, Carmen Santangelo, Tiziana Pietrangelo, Stefania Fulle, Vittore Verratti   +6 more
wiley   +1 more source

The hypoxic ventilatory response and arousal burden predict the magnitude of ventilatory long‐term facilitation in humans with obstructive sleep apnoea

Experimental Physiology, EarlyView.
Abstract The magnitude of progressive augmentation (PA) and ventilatory long‐term facilitation (vLTF) are two forms of respiratory plasticity that are enhanced in some humans with obstructive sleep apnoea (OSA). This response might be linked to repeated nocturnal exposure to intermittent hypoxia or other traits connected to OSA.
Jason H. Mateika, Danny Hammo, Dylan M. Kissane, Ali Azarbarzin   +3 more
wiley   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Acute ketone monoester ingestion lowers resting cerebral blood flow: a randomized cross‐over trial

The Journal of Physiology, EarlyView.
Abstract figure legend This double‐blind, placebo‐controlled, randomized cross‐over trial investigated the effects of ketone monoester (KME) ingestion on resting cerebral blood flow (CBF) in young adults. We demonstrate that KME supplementation lowers CBF in a dose‐dependent manner over 2‐houra post‐ingestion, whereas CBF remained unchanged following ...
Aedan J. Rourke, Claudia M.S. Yong, Geoff B. Coombs, Addriana R. Odisho, Jenna A. Nash, Jack Bone, Baraa K. Al‐Khazraji, Jeremy J. Walsh   +7 more
wiley   +1 more source