Results 61 to 70 of about 991,088 (288)

Pulmonary‐Targeted Nanoparticles Interrupt the Malignant Mechanical and Biochemical Signaling Crosstalk for Idiopathic Pulmonary Fibrosis Therapy

open access: yesAdvanced Science, EarlyView.
Idiopathic pulmonary fibrosis (IPF) progression is driven by TGF‐β induced biochemical signals and mechanical signals from increased ECM stiffness. Pulmonary‐targeted VB‐RT NPs not only eliminate excessive ROS and penetrate the dense ECM collagen barrier via NO release, but also simultaneously interrupt the persistent malignant between mechanical and ...
Xue‐Na Li   +11 more
wiley   +1 more source

Non-Clinic Blood Pressure Measurement – More Light, Less Darkness

open access: yesAsian Journal of Medical Sciences, 2018
Non-clinic blood pressure measurements are very important in confirming diagnosis of hypertension and they give us an idea of associated cardiovascular risk more precisely than clinic BP measurements.
Vinay Kapur
doaj   +1 more source

Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts

open access: yesAdvanced Science, EarlyView.
Cellular senescence contributes to disease burden in cardiovascular disease (CVD) and aging, highlighting the need to understand its induction. In primary cardiac fibroblasts, reduced strain and increased frequency, mimicking CVD, elicit a distinct senescent phenotype compared to oxidative stress.
Stephanie E. Schneider   +5 more
wiley   +1 more source

The clinical role of daily blood pressure monitoring for the management of patients at the ambulatory stage

open access: yesСучасні медичні технології
The aim of the work is to analyze and evaluate the clinical role of daily blood pressure monitoring for the management of patients with arterial hypertension. Materials and methods.
O. S. Kulbachuk   +3 more
doaj   +1 more source

Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia

open access: yesAdvanced Science, EarlyView.
Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt   +5 more
wiley   +1 more source

Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring [PDF]

open access: gold, 2022
Francesca Coccina   +10 more
openalex   +1 more source

Disruption of the Blood–Brain Barrier Predicts Progression of Cerebral Small Vessel Disease White Matter Hyperintensities

open access: yesAnnals of Neurology, EarlyView.
Objective The objective of this study was to test if blood–brain barrier (BBB) disruption, detected using dynamic susceptibility contrast (DSC) imaging, would predict progression of white matter hyperintensities (WMHs) over the subsequent year in patients with chronic cerebrovascular disease. Methods The study included patients with a history of stroke
Richard Leigh   +4 more
wiley   +1 more source

A possible cause of epistaxis: increased masked hypertension prevalence in patients with epistaxis

open access: yesBrazilian Journal of Otorhinolaryngology
Introduction Epistaxis and hypertension are frequent conditions in the adult population. Masked hypertension is defined as a clinical condition in which a patient's office blood pressure level is
Baran Acar   +6 more
doaj   +1 more source

Efficacy and Safety of Dotinurad Versus Febuxostat for the Treatment of Gout: A Randomized, Multicenter, Double‐Blind, Phase 3 Trial in China

open access: yesArthritis &Rheumatology, EarlyView.
Objective Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicenter, randomized, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad ...
Jia Sun   +19 more
wiley   +1 more source

1. ARTERIAL STIFFNESS IN MASKED HYPERTENSION AND TRUE HYPERTENSION

open access: yesArtery Research, 2009
Background: Masked hypertension (MH) has been drawing attention recently because this condition is often seen in untreated and treated individuals and is associated with target organ damage and a poor cardiovascular prognosis.
Young-Soo Lee   +9 more
doaj   +1 more source

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