Results 71 to 80 of about 991,088 (288)

A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis

open access: yesArthritis &Rheumatology, Accepted Article.
Background Individuals with serum elevations of anti‐cyclic citrullinated peptide (anti‐CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for the prevention of RA in such ‘at‐risk’ individuals. However, hydroxychloroquine (HCQ) is used without supporting clinical trial evidence.
Kevin D. Deane   +33 more
wiley   +1 more source

White Coat Hypertension and Masked Hypertension Among Omani Patients Attending a Tertiary Hospital for Ambulatory Blood Pressure Monitoring

open access: yesOman Medical Journal, 2015
Objectives: Our study aimed to estimate the rate of white coat hypertension (WCH) and effect, and masked hypertension in patients attending a tertiary care hospital for 24 hour ambulatory blood pressure monitoring (24-h ABPM).
Khamis Al-Hashmi   +7 more
doaj   +1 more source

Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the WHO pharmacovigilance database

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportionality/clustering analysis from the WHO pharmacovigilance database.
Alex Hlavaty   +4 more
wiley   +1 more source

Masked uncontrolled hypertension: Prevalence and predictors

open access: yesThe Egyptian Heart Journal, 2018
Background: There are limited data on ‘masked uncontrolled hypertension’ (MUCH) in patients with treated and apparently well-controlled BP is unknown. Objectives: To define the prevalence and predictors of MUCH among hypertensive patients with controlled
Ghada Youssef   +4 more
doaj   +1 more source

Clinical features and predictors of masked uncontrolled hypertension from the Korean Ambulatory Blood Pressure Monitoring Registry [PDF]

open access: gold, 2021
Hyun‐Jin Kim   +11 more
openalex   +1 more source

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

open access: yesChemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo   +3 more
wiley   +1 more source

Prevalence and Associated Factors of Chronic Diseases Among Adults in Somaliland: A Multilevel Analysis From the 2020 SLHDS

open access: yesChronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Chronic diseases represent a growing public health challenge globally, particularly in developing regions like Sub‐Saharan Africa. Somaliland faces a dual burden of communicable and non‐communicable diseases amidst post‐conflict recovery, yet data on non‐communicable disease (NCD) prevalence and determinants remain scarce.
Abdirahman Omer Ali   +5 more
wiley   +1 more source

A precision trial case study for heterogeneous treatment effects in obstructive sleep apnea

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Precision medicine tailors treatments to individual patient characteristics, which is especially valuable for obstructive sleep apnea (OSA), where treatment responses vary widely. Traditional trials often overlook subgroup differences, leading to suboptimal recommendations.
Lara Maleyeff   +3 more
wiley   +1 more source

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