Results 71 to 80 of about 57,278 (332)

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Increased masked hypertension prevalence in patients with obesity

Clinical and Experimental Hypertension, 2018
Objectives: Masked hypertension is associated with an increased risk for cardiovascular conditions. The aim of the study was to evaluate the relationship obesity parameters, including body weight, waist circumference, and body mass index.
Selçuk Özkan, Naim Ata, Bunyamin Yavuz
doaj   +1 more source

Ambulatory blood pressure monitoring for the management of hypertension

Chinese Medical Journal, 2022
. Ambulatory blood pressure monitoring (ABPM) has become indispensable in the current management of hypertension. ABPM is particularly useful in the accurate diagnosis of hypertension. Its diagnostic thresholds had been recently established based on hard
Yibang Cheng, Yan Li, Jiguang Wang, Ningning Wang, Yuanyuan Ji   +4 more
doaj   +1 more source

Identifying masked uncontrolled hypertension in the community pharmacy setting [PDF]

, 2015
© 2015 Wolters Kluwer Health, Inc. Masked uncontrolled hypertension (MUCH) is associated with an increased cardiovascular risk. This condition is frequent in the community pharmacy (i.e., CP-MUCH), but there is no evidence on the factors associated with ...
Benrimoj, SI, De La Sierra, A, Durks, D, Jiménez-Monleón, JJ, Martínez-Martínez, F, Sabater-Hernández, D, Sendra-Lillo, J   +6 more
core   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation. [PDF]

, 2015
Regular consumption of chocolate and cocoa products has been linked to reduced cardiovascular mortality. This study compared the effects of high flavanol dark chocolate (HFDC; 1064mg flavanols/day for 6 weeks) and low flavanol dark chocolate (LFDC; 88mg ...
Akita, Armstrong, Atholl Johnston, Avolio, Balzer, Buijsse, Buijsse, Butcher, Curtis, Curtis, Custodis, David J. Collier, Duprez, Engler, Flammer, Flammer, Fredholm, Grassi, Grassi, Gresele, Gu, Gurvinder Rull, Heiss, Hermann, Holland, Holt, Innes, Janszky, Julian Shiel, Kokubo, Kris-Etherton, Kris-Etherton, Lakatta, Langer, Larsson, Larsson, Laurent, Lopez-Garcia, Manisty, Martina H. Lundberg, Murphy, Pereira, Rambaran, Rein, Ried, Roger Corder, Schroeter, Sever, Sharman, Smolenski, Taubert, Thorin, Timothy D. Warner, Varughese, Williams, Yu, Zetty N. Mohd-Zain   +56 more
core   +1 more source

Review of Memristors for In‐Memory Computing and Spiking Neural Networks

Advanced Intelligent Systems, EarlyView.
Memristors uniquely enable energy‐efficient, brain‐inspired computing by acting as both memory and synaptic elements. This review highlights their physical mechanisms, integration in crossbar arrays, and role in spiking neural networks. Key challenges, including variability, relaxation, and stochastic switching, are discussed, alongside emerging ...
Mostafa Shooshtari, Teresa Serrano‐Gotarredona, Bernabé Linares‐Barranco   +2 more
wiley   +1 more source

Masked uncontrolled hypertension [PDF]

Journal of Hypertension, 2019
Juan M, Mejia-Vilet, Udayan, Bhatt, Daniel J, Birmingham, Cristina, Arce, Christopher J, Hebert, Samir V, Parikh, Haikady N, Nagaraja, Lee A, Hebert   +7 more
  +8 more sources

BLOOD PRESSURE PHENOTYPES IN TREATED HYPERTENSIVE PATIENTS IN SUMMER AND WINTER: FOCUS ON MASKED UNCONTROLLED HYPERTENSION. PART 1: BLOOD PRESSURE PHENOTYPES PREVALENCE

Рациональная фармакотерапия в кардиологии, 2017
Background. The seasonal variability of blood pressure (BP) and cardiovascular morbidity and mortality motivates researchers to search  for the new approaches of the antihypertensive treatment (AHT) efficacy assessment, including the analysis of ...
M. I. Smirnova, V. M. Gorbunov, S. A. Boytsov, M. M. Loukianov, A. M. Kalinina, D. A. Volkov, A. D. Deev, Y. N. Koshelyaevskaya, E. N. Belova   +8 more
doaj   +1 more source

Autonomic dysregulation and phenobarbital in patients with masked primary hypertension

Heliyon, 2020
Introduction: Primary hypertension can be masked and be responsible of a severe impact on the target bodies. The purpose of this study was to see if Phenobarbital at low dose is able to decrease the sympathetic hyperactivity assessed by cardiovascular ...
Mustapha EL. Bakkali, Souad Aboudrar, Taoufiq Dakka, Halima Benjelloun   +3 more
doaj   +1 more source