Results 81 to 90 of about 485,499 (295)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

The Palomar Kernel Phase Experiment: Testing Kernel Phase Interferometry for Ground-based Astronomical Observations

open access: yes, 2015
At present, the principal limitation on the resolution and contrast of astronomical imaging instruments comes from aberrations in the optical path, which may be imposed by the Earth's turbulent atmosphere or by variations in the alignment and shape of ...
Greenbaum, Alexandra   +7 more
core   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Reusing Logic Masking to Facilitate Hardware Trojan Detection [PDF]

open access: yes, 2016
Hardware Trojan (HT) and Integrated Circuit (IC)/ Intellectual Property (IP) piracy are important threats which may happen in untrusted fabrication foundries.
Beroulle, Vincent   +2 more
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

An investigation into the efficacy of methods commonly employed by mix engineers to reduce frequency masking in the mixing of multitrack musical recordings [PDF]

open access: yes, 2015
Studio engineers use a variety of techniques to reduce frequency masking between instruments when mixing multi-track musical recordings. This study evaluates the efficacy of three techniques, namely mirrored equalization, frequency spectrum sharing and ...
Dewey, Christopher   +1 more
core  

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz   +25 more
wiley   +1 more source

Masking: A New Perspective of Noisy Supervision [PDF]

open access: yes, 2018
It is important to learn various types of classifiers given training data with noisy labels. Noisy labels, in the most popular noise model hitherto, are corrupted from ground-truth labels by an unknown noise transition matrix.
Han, Bo   +6 more
core  

Monaural Singing Voice Separation with Skip-Filtering Connections and Recurrent Inference of Time-Frequency Mask

open access: yes, 2017
Singing voice separation based on deep learning relies on the usage of time-frequency masking. In many cases the masking process is not a learnable function or is not encapsulated into the deep learning optimization.
Bengio, Yoshua   +5 more
core   +1 more source

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