Results 21 to 30 of about 71,271 (202)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Frame Theory for Signal Processing in Psychoacoustics

, 2016
This review chapter aims to strengthen the link between frame theory and signal processing tasks in psychoacoustics. On the one side, the basic concepts of frame theory are presented and some proofs are provided to explain those concepts in some detail ...
A. Bregman, A. Janssen, A. Ron, A.V. Oppenheim, A.V. Oppenheim, B. Laback, B. Laback, B.C.J. Moore, B.C.J. Moore, B.R. Glasberg, C. Heil, C. Heil, C. Wiesmeyr, C.J. Plack, D. Soderquist, D. Wang, D.D. Greenwood, D.T. Stoeva, D.T. Stoeva, E. Hernández, E. Ravelli, E. Zwicker, E. Zwicker, E.A. Lopez-Poveda, G. Chardon, G. Kidd Jr, G. Matz, H. Bölcskei, H. Fastl, I. Daubechies, J. Kovačević, J. Leng, J.J. Benedetto, J.J. O’Donovan, J.S. Garofolo, K. Gröchenig, L. Chai, L.N. Trefethen, M. Bownik, M. Bézat, M. Elad, M. Unoki, M. Vetterli, N. Holighaus, N. Holighaus, N. Perraudin, N.K. Bari, O. Christensen, O. Christensen, O. Christensen, P. Balazs, P. Balazs, P. Balazs, P. Balazs, P. Balazs, P. Balazs, P. Balazs, P. Balazs, P. Casazza, P. Søndergaard, P. Vaidyanathan, P.G. Casazza, P.G. Casazza, R.D. Patterson, R.J. Duffin, R.M. Young, S. Strahl, T. Irino, T. Painter, T. Werther, T.S. Gunawan, W. Jesteadt, X. Valero, X. Zhao, Z. Cvetković   +74 more
core   +1 more source

Altered Dynamic Functional Network Connectivity in Post‐Stroke Aphasia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Previous studies examining post‐stroke aphasia (PSA) patients via resting‐state functional magnetic resonance imaging (rs‐fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients ...
Guihua Xu, Yongsheng Wu, Junyu Qu, Rui Zhu, Wenwen Xu, Jiaxiang Xin, Dawei Wang   +6 more
wiley   +1 more source

Ion masking improves resolution in quadrupole mass spectrometers [PDF]

, 1973
Mass spectrometers analyze molecular composition by determining mass-to-charge ratio of ion fragments of molecules. Study adds significantly to quantitative understanding of quadrupole mass filter.
Ierokomos, N., Ruecker, M. R.
core   +1 more source

When Causal Intervention Meets Adversarial Examples and Image Masking for Deep Neural Networks

, 2019
Discovering and exploiting the causality in deep neural networks (DNNs) are crucial challenges for understanding and reasoning causal effects (CE) on an explainable visual model.
Chen, Pin-Yu, Liu, Yi-Chieh, Ma, Xiaoli, Tsai, Yi-Chang James, Yang, Chao-Han Huck   +4 more
core   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

A Systematic Search for X-ray Cavities in the Hot Gas of Galaxy Groups

, 2010
We have performed a systematic search for X-ray cavities in the hot gas of 51 galaxy groups with Chandra archival data. The cavities are identified based on two methods: subtracting an elliptical beta model fitted to the X-ray surface brightness, and ...
Benson, Best, Blanton, Brüggen, Bîrzan, Bîrzan, Cavaliere, Churazov, Condon, Diehl, Diehl, Diehl, Diehl, Dong, Dursi, Fukazawa, Gastaldello, Giacintucci, Humphrey, Jesper Rasmussen, John S. Mulchaey, Jones, Jones, Kraft, Li, Liu, Machacek, McNamara, Mohr, Morita, Nakamura, Nakamura, Nulsen, O’Neill, Rafferty, Rafferty, Randall, Robinson, Ruobing Dong, Scannapieco, Sternberg, Sun, Wise   +42 more
core   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source