Results 91 to 100 of about 1,846,404 (321)

Lower Central Fat Increase Risk of One-Year Muscle Mass Loss in Menopausal Women

Mediators of Inflammation, 2020
Background. Hormonal changes had been found in menopausal women. Muscle and bone mass decline after menopause and with aging, increasing the risk for sarcopenia and osteoporosis in later life.
Ying-Chou Chen, Wei-Che Lin, Tien-Tsai Cheng, Jia-Feng Chen, Shan-Fu Yu, Chung-Yuan Hsu   +5 more
doaj   +1 more source

Mass Loss from Early-Type Stars [PDF]

Symposium - International Astronomical Union, 1970
Following the detailed study of four very high luminosity OB stars, a survey has been made for spectroscopic evidence of mass loss in a number of early-type supergiants. A list of spectroscopic criteria is given and the mass loss estimates for 24 stars plotted on the HR diagram.
openaire   +1 more source

Mass Loss: Its Effect on the Evolution and Fate of High-Mass Stars

, 2014
Our understanding of massive star evolution is in flux, due to recent upheavals in our view of mass loss, and observations of a high binary fraction among O-type stars. Mass-loss rates for standard metallicity-dependent winds of hot stars are now thought
Smith, Nathan
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Horizontal Branch Morphology and Mass Loss in Globular Clusters

, 2008
The connection between mass loss on the red giant branch (RGB) and horizontal branch (HB) morphology in globular clusters (GCs) has long been acknowledged but the mechanisms governing mass loss remains poorly understood from a theoretical perspective ...
Aaron Dotter, Catelan, Catelan, D'Antona, Dotter, Ferraro, Lee, Lee, Milone, Origlia, Origlia, Piotto, Pritzl, Rey, VandenBerg, Zinn   +15 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Mass loss from Luminous Blue Variables [PDF]

International Astronomical Union Colloquium, 1989
Luminous Blue Variables (LBV’s) are losing mass at a rate which is higher than in normal stars of the same luminosity. This high mass loss is evident from the occurrence of P Cygni profiles in the visual spectrum, the large numbers of UV lines which are Doppler shifted or show P Cygni profiles and the large IR excess or radio free-free emission.
openaire   +1 more source

Neglecting the porosity of hot-star winds can lead to underestimating mass-loss rates

, 2007
Context: The mass-loss rate is a key parameter of massive stars. Adequate stellar atmosphere models are required for spectral analyses and mass-loss determinations.
Feldmeier, A., Hamann, W. -R., Oskinova, L. M.   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source