Results 101 to 110 of about 1,846,404 (321)

Implications of the metallicity dependence of Wolf-Rayet winds

, 2006
Aims: Recent theoretical predictions for the winds of Wolf-Rayet stars indicate that their mass-loss rates scale with the initial stellar metallicity in the local Universe.We aim to investigate how this predicted dependence affects the models of Wolf ...
Asplund, Crowther, de Jager, Eggleton, Eldridge, Eldridge, Ensman, Gräfener, Hamann, Heger, Howarth, J. J. Eldridge, J. S. Vink, Kroupa, Lucy, Maeder, Massey, Massey, Massey, Massey, Meynet, Meynet, Nugis, Petrovic, Pols, Popham, Prantzos, Puls, Vink, Vink, Vink   +30 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Influence of XUV radiation on Pv ionization fraction in hot star winds

, 2012
Different diagnostics of hot star wind mass-loss rates provide results that are difficult to reconcile with each other. The widely accepted presence of clumping in hot star winds implies a significant reduction of observational mass-loss rate estimates ...
Abbott, Anders, Asplund, Bouret, Castor, Cohen, Cohen, Cohen, Cohen, Crowther, Drew, Feldmeier, Feldmeier, Fullerton, Gagné, Hamann, Hamann, Hummer, Ignace, Jiří Krtička, Jiří Kubát, Kaastra, Krtička, Krtička, Krtička, Krtička, Kubát, Kubát, Kupka, Lamers, Lanz, Lanz, Lee, Leitherer, Leutenegger, Lucy, Lucy, Lucy, MacFarlane, Martins, Martins, Massa, Mihalas, Mihalas, Muijres, Okazaki, Oskinova, Oskinova, Oskinova, Owocki, Owocki, Owocki, Pauldrach, Pauldrach, Pauldrach, Piskunov, Poe, Puls, Puls, Puls, Rauw, Rauw, Repolust, Sana, Seaton, Smith, Sundqvist, Umeda, Verner, Verner, Vink, Waldron, Waldron, Woitke, Šurlan, Šurlan   +75 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Solar Cycle Variation of the Mass-loss Rate of Coronal Mass Ejections

The Astrophysical Journal Supplement Series
Coronal mass ejections (CMEs) are known as the main drivers of the most severe space weather disturbances. Usually, the most severe geomagnetic storms are caused by massive and fast CMEs.
Yijia Tang, Xiaojuan Zhang, Hui Deng, Feng Wang, Linhua Deng, Ying Mei   +5 more
doaj   +1 more source

Supernovae from Red Supergiants with Extensive Mass Loss

, 2011
We calculate multicolor light curves (LCs) of supernovae (SNe) from red supergiants (RSGs) exploded within dense circumstellar medium (CSM). Multicolor LCs are calculated by using a multi-group radiation hydrodynamics code STELLA. If CSM is dense enough,
Andrews, Arcavi, Baklanov, Bersten, Bessell, Blinnikov, Blinnikov, Blinnikov, Blinnikov, Boissier, Botticella, Boyer, Brown, Cardelli, Chevalier, Chugai, Dessart, Dessart, Dessart, Dessart, Elena I. Sorokina, Elias-Rosa, Falk, Falk, Filippenko, Fraser, Georgy, Hamuy, Heger, Heger, Kasen, Li, Metzger, Morrissey, Nozomu Tominaga, Petr V. Baklanov, Pozzo, Rabinak, Schlegel, Schlegel, Sergei I. Blinnikov, Smartt, Smartt, Smith, Smith, Takashi Moriya, Tominaga, Tominaga, Utrobin, Utrobin, van Marle, Weaver, Woosley, Woosley, Woosley, Yoon   +55 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Angular Momentum Loss during Stable Mass Transfer onto a Compact Object: The Effect of Mass Loss via Accretion Disk Winds

The Astrophysical Journal
We use an analytic framework to calculate the evolution of binary orbits under a physically motivated model that accounts for angular momentum loss associated with winds from an accretion disk around the compact-objected accretor.
Monica Gallegos-Garcia, Jonatan Jacquemin-Ide, Vicky Kalogera   +2 more
doaj   +1 more source

Dust Production and Mass Loss in the Galactic Globular Cluster NGC 362

, 2009
We investigate dust production and stellar mass loss in the Galactic globular cluster NGC 362. Due to its close proximity to the Small Magellanic Cloud (SMC), NGC 362 was imaged with the IRAC and MIPS cameras onboard the Spitzer Space Telescope as part ...
Barbara Whitney, Barmby, Bellazzini, Bernie Shiao, Blum, Bolatto, Boyer, Boyer, Boyer, Brian Babler, Catelan, Charles Engelbracht, Clement, Dale, Epchtein, Freire, Gnedin, Gustafsson, Hanner, Harris, Harris, Iain McDonald, Ita, Jacco Th. van Loon, Joana M. Oliveira, Joe Hora, Jäger, Karl D. Gordon, Karl Misselt, Lebzelter, Margaret Meixner, Marilyn Meade, Marta Sewilo, Martha L. Boyer, Matsunaga, McLaughlin, Meixner, Miwa Block, Murakami, Mészáros, Nenkova, Onaka, Origlia, Origlia, Remy Indebetouw, Sarajedini, Schröder, Skrutskie, Smith, Steve Bracker, Tucholke, Werner, Zacharias, Zaritsky   +53 more
core   +1 more source