Results 101 to 110 of about 225,747 (287)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Effect of Seismicity and Tectonic‐Glacial Interactions on Submarine Megaslides

Geophysical Research Letters
Enhanced sedimentation at glacial margins can produce submarine megaslides (>10,000 km3). We report a single megaslide in the Surveyor Fan, Gulf of Alaska. Minimum extant size is ∼16,124 km2 in area and ∼9,080 km3 in volume.
Sean P. S. Gulick, Robert S. Reece, Derek E. Sawyer, Gail L. Christeson, Brian K. Horton   +4 more
doaj   +1 more source

Capacity loss of non-aqueous Li-Air battery due to insoluble product formation: Approximate solution and experimental validation [PDF]

, 2019
In this paper, we present a study of Lithium (Li)-air battery capacity by accounting for the voltage loss associated with the electrode passivation and transport resistance caused by insoluble product formation.
Read, JA, Wang, Y, Yuan, H
core  

Recent mass transport deposits in the Gulf of Cagliari

Marine Geology
Sedimentary deposits due to slope failures and submarine landslides are common on continental margins. The availability of five new high resolution 2D multi-channel seismic profiles, integrated by Multibeam data, provides unprecedented insight into the shallow submarine geomorphology of the Gulf of Cagliari.
Caradonna, Maria Cristina, Del Ben, Anna, Pini, Gian Andrea, Geletti, Riccardo, Frisicchio, Veronica   +4 more
openaire   +2 more sources

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Unlocking the Style and Timing of Submarine Landslides: Insights From the Tuaheni North Slide, Hikurangi Margin

Geophysical Research Letters
We investigate the morphology and timing of Tuaheni North, a large submarine landslide within the Tuaheni Landslide Complex on Aotearoa New Zealand's Hikurangi Margin.
Alexey Portnov, Jess I. T. Hillman, Sally Watson, Ann E. Cook, Andreas Laake, Francisco José Lobo   +5 more
doaj   +1 more source

Revisiting the Pyhäsalmi volcanic complex, western Finland: new insights from volcanic-facies mapping [PDF]

Bulletin of the Geological Society of Finland
The Pyhäsalmi Volcanogenic Massive Sulfide (VMS) deposit, hosted by volcanic rocks of the 1.93–1.91 Ga Vihanti–Pyhäsalmi–Rautalampi belt, is the largest base metal sulfide deposit in Finland (75.7 Mt at 0.9 wt.% Cu, 1.9 wt.% Zn, 0.4 g/t Au, and 14.1 g/t ...
Janne Hokka, Ville Järvinen
doaj   +1 more source