Results 61 to 70 of about 225,747 (287)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Shallow‐Water Tsunami Deposits: Evidence From Sediment Cores and Numerical Wave Propagation of the 1601 CE Lake Lucerne Event

Geochemistry, Geophysics, Geosystems, 2021
The 1601 CE earthquake (Mw ca. 5.9) in “Unterwalden,” Central Switzerland, triggered multiple subaqueous mass movements and a subaerial rockfall that generated tsunami waves with run‐up heights of up to 4 m and several hundred meters of inundation along ...
Valentin Nigg, Paola Bacigaluppi, David F. Vetsch, Hendrik Vogel, Katrina Kremer, Flavio S. Anselmetti   +5 more
doaj   +1 more source

Predicting the depositional environments and transportation mechanisms of sediments using granulometric parameters, bivariate and multivariate analyses [PDF]

, 2019
Grain size distribution and classes present in sedimentary rocks are responsive to the physical changes of the transporting media and the basin of deposition.
Ikhane, Phillips R., Oladipo, Olajide Vincent, Oyebolu, Olalekan Olayiwola   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Volcanic Flank Collapse, Secondary Sediment Failure and Flow‐Transition: Multi‐Stage Landslide Emplacement Offshore Montserrat, Lesser Antilles

Geochemistry, Geophysics, Geosystems
Volcanic flank collapses, especially those in island settings, have generated some of the most voluminous mass transport deposits on Earth and can trigger devastating tsunamis.
Michel Kühn, Christian Berndt, Sebastian F. L. Watt, Matthew J. Hornbach, Sebastian Krastel, Kristina Sass, Steffen Kutterolf, Tim Freudenthal, Katrin Huhn, Jens Karstens, Bettina Schramm, Judith Elger, Christoph Böttner, Dirk Klaeschen   +13 more
doaj   +1 more source

Effects of population density on the sediment mixing induced by the gallery-diffusor Hediste (Nereis) diversicolor O.F. Müller, 1776 [PDF]

, 2006
The aim of this work was to quantify the intensity of sediment mixing induced by the gallery-diffusor (functional bioturbation group) Hediste diversicolor as a function of density, using particles tracers (luminophores).
Duport, Eric, Gilbert, Franck, Stora, Georges, Tremblay, Pierre   +3 more
core   +6 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Dark matter sterile neutrinos in stellar collapse: alteration of energy/lepton number transport and a mechanism for supernova explosion enhancement [PDF]

, 2006
We investigate matter-enhanced Mikheyev-Smirnov-Wolfenstein (MSW) active-sterile neutrino conversion in the $\nu_e \rightleftharpoons \nu_s$ channel in the collapse of the iron core of a pre-supernova star.
A. Boyarsky, A. Mezzacappa, A. Mezzacappa, George M. Fuller, Jun Hidaka, S. P. Mikheyev   +5 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Propagation and deposition of stony debris flows at channel confluences [PDF]

, 2015
The fluid dynamics of stony debris flows generated in two small tributaries adjacent to each other and flowing into a main receiving channel was analyzed experimentally at a laboratory scale.
Foti, E., Lanzoni, Stefano, Stancanelli, LAURA MARIA   +2 more
core   +1 more source