Results 71 to 80 of about 225,747 (287)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Effect of Shell Thickness on Electron and Hole Transmission Probabilities of a ZnSe/ZnS Core- Shell Quantum Dot [PDF]

Materials Research, 2018
In this paper we report the effect of shell thickness on transmission probabilities of electrons and holes in the strained configuration of zinc-selenide/zinc-sulphide (ZnSe/ZnS) core-shell quantum dot.
Bashir Mohi Ud Din Bhat, Khurshed A. Shah   +1 more
doaj   +1 more source

Pattern formation during the evaporation of a colloidal nanoliter drop: a numerical and experimental study

, 2010
An efficient way to precisely pattern particles on solid surfaces is to dispense and evaporate colloidal drops, as for bioassays. The dried deposits often exhibit complex structures exemplified by the coffee ring pattern, where most particles have ...
, , Attinger D, Bhardwaj R, Bird R B, Burnett D S, Daniel Attinger, deGennes P G, Fuchs N A, Gillen G, Goodwin R D, Haferl S, Heim T, Krishna P, Lide D R, Maxwell J C, Ondarcuhu T, Popov Y, Rajneesh Bhardwaj, VanWylen G J, Vargaftik N B, Xiaohua Fang, Xu J Attinger D, Zheng R   +23 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

An Adapted Rotating Disk Electrode Setup to Test Nonstandard‐Disk Electrodes: On the Enhanced Hydrogen Evolution Performance of Model Dewetted Pt Nanoparticles Versus Pt Thin Films under Hydrodynamic Conditions

ChemElectroChem
A common approach to test electrocatalyst nanoparticles (NPs) for electrolyzers and fuel cells is to deposit catalyst particles (e.g., Pt/carbon) onto standard disk electrodes (e.g., glassy carbon) by making use of inks based on binders (ionomers such as
Shreyas Harsha, Lasse Wichmann, Guido Mul, Marco Altomare   +3 more
doaj   +1 more source

A Channel Network Model for Sediment Dynamics Over Watershed Management Time Scales

Journal of Advances in Modeling Earth Systems, 2020
A mountain watershed network model is presented for use in decadal to centurial estimation of source‐to‐sink sediment dynamics. The model requires limited input parameters and can be effectively applied over spatial scales relevant to management of ...
Claire Beveridge, Erkan Istanbulluoglu, Christina Bandaragoda, Allison M. Pfeiffer   +3 more
doaj   +1 more source

Experimental Study on Aerosol Removal Characteristics from Wall Surfaces in Condensation Wash-down Environment

Yuanzineng kexue jishu, 2023
For the nuclear reactor that experienced a severe radioactive leakage accident, there will be radioactive aerosols dispersed in vapor phase space of the containment vessel.
SUN Qingyang1;GU Haifeng1,*;LI Jingjing2;ZHOU Yanmin1;ZHANG Zhigang1;WANG Xiao1;E Xinnuo1;LI Tao1
doaj   +1 more source

Numerical simulation of colloidal dispersion filtration: description of critical flux and comparison with experimental results [PDF]

, 2005
During filtration via membrane processes, colloids accumulate at the porous surface leading to fouling phenomena. In this study, a rigorous simulation of momentum and mass transfer using CFD modelling has been developed to describe such an accumulation ...
Bacchin, Bacchin, Benjamin Espinasse, David F. Fletcher, Einstein, Elimelech, Field, Fletcher, Jönsson, Kissa, Landman, Patrice Bacchin, Pierre Aimar, Russel, Sherwood, Wiley, Yolaine Bessiere   +16 more
core   +4 more sources

A two-layer shallow flow model with two axes of integration, well-balanced discretization and application to submarine avalanches [PDF]

, 2020
We propose a two-layer model with two different axes of integration and a well-balanced finite volume method. The purpose is to study submarine avalanches and generated tsunamis by a depth-averaged model with different averaged directions for the fluid ...
Bouchut, François, Delgado Sánchez, Juan Manuel, Fernández Nieto, Enrique Domingo, Mangeney, Anne, Narbona Reina, Gladys   +4 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source