Results 131 to 140 of about 12,799,816 (313)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Spartan Daily, January 25, 1939 [PDF]
, 1939 Volume 27, Issue 70https://scholarworks.sjsu.edu/spartandaily/2860/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Spartan Daily, March 26, 1963 [PDF]
, 1963 Volume 50, Issue 95https://scholarworks.sjsu.edu/spartandaily/4442/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Spartan Daily, February 28, 2000 [PDF]
, 2000 Volume 114, Issue 22https://scholarworks.sjsu.edu/spartandaily/9519/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Spartan Daily, February 24, 2005 [PDF]
, 2005 Volume 124, Issue 20https://scholarworks.sjsu.edu/spartandaily/10092/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Spartan Daily, March 17, 2004 [PDF]
, 2004 Volume 122, Issue 33https://scholarworks.sjsu.edu/spartandaily/9968/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source