Results 171 to 180 of about 12,799,816 (313)
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Establishment of a Purge and Trap Continuous-Flow Isotope Ratio Mass Spectrometer System for Analysis of Stable Nitrate Isotopes (δ<sup>15</sup>N and δ<sup>18</sup>O) in Water Samples by Ti(III) Reduction. [PDF]
Gcakasi MN, Stumpp C, Watzinger A.
europepmc +1 more source
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Development of an Atmospheric-Pressure Photoionization Source for VOC Detection With a Miniature High-Pressure Mass Spectrometer. [PDF]
Rowland AM +6 more
europepmc +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Improving systematic uncertainties on precision two-body mass measurements. [PDF]
Chu A, Liu Y, Needham M.
europepmc +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Automated Near Real-Time QC for LC-HRMS. [PDF]
Mohr MJ +6 more
europepmc +1 more source

