Results 51 to 60 of about 3,606,146 (197)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

System of Value Orientations of Personality and Social Communities: Structural and Dynamic Model and its Application in Psychological Research and Psychological Practice

Вестник Кемеровского государственного университета, 2020
The present article is an extended version of the report delivered at the meeting of the Presidium of the Russian Academy of Education. The paper introduces an authentic structural and dynamic model of the system of value orientations of the individual ...
M. S. Yanitskiy
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

INFORMATION AGENDA AS A FACTOR OF SOCIETAL EFFICIENCY

Освітній дискурс
Relevance of the research. The a priori problem lies in the fact that the information agenda does not possess the status of subjectivity; rather, it belongs to the category of classical objects that are shaped at the discretion of full-fledged subjects ...
Lesya Panchenko, Volodymyr Petrenko
doaj   +1 more source

Organization of Oral Advertising and Agitation in the Years of the Great Patriotic War (On Materials of North Ossetia)

RUDN Journal of Russian History, 2020
This author examines the activities of Soviet party-state bodies in the field of propaganda among the population in the North Ossetian Autonomous Soviet Socialist Republic (North Ossetia) during the Great Patriotic War.
Ruslan G. Bimbasov
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Brain endogenous feedback and degrees of consciousness

, 2012
We present a model able to account for the mechanisms supporting different degrees of consciousness. We support our proposal with recent evidence from brain morphology and physiology, which indicate that the central nervous system contains two parallel ...
Pereira Jr., Alfredo [UNESP], Carrara-Augustenborg, Claudia   +1 more
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The techniques of clinical hypnosis and ‘altered states of consciousness’ in pain and suffering relief, at the end of life.

, 2011
5.3 Hypnosis 257 The techniques of clinical hypnosis and ‘altered states of consciousness’ in pain and suffering relief, at the end of life. Paola Brugnoli Cancer pain and chronic non malignant pain, can have devastating effects on patients’ end of
Brugnoli, Maria Paola
core   +1 more source