Results 51 to 60 of about 1,109,685 (262)
Copper face of ancient America: representation of Mesoamerican civilizations in American pulp-magazine Weird tales in the interwar period [PDF]
Латиноамериканский исторический альманахIn the Interwar period different form of Ancient civilization had been one the most frequent theme in American popular culture. Lost Indian civilization wasn’t exception, but this is-sue is still poorly investigate in the popular culture’s field.
Lapaev Nikita
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Studia Humanitatis, 2017 The article for the first time in the Russian Humanities considers the phenomenon of glamour through the prism of universal aesthetic categories. The essence of the conception is to explore the phenomenon of glamour not in the sphere of its existence ...
Nikolsky Evgeny Vladimirovich
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Culture system for Wolffia globosa L. (Lemnaceae) for hygiene human food [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2015 This study aimed to develop a suitable culture system for the mass production of Wolffia globosa for human consumption. W. globosa was grown in five different culture systems (static, vertical aeration, horizontal surface agitation, system with top ...
Nisachol Ruekaewma +2 more
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Le canzonette alla sbarra. Pci e nuova sinistra tra rock ‘n roll e Sanremo (1956-1964)
Diacronie. Studi di Storia Contemporanea, 2023 Between the end of the fifties and the first half of the sixties, the PCI was hit by the radical changes that took place following the “economic boom”. On the basis of economic growth, cultural consumption also changes profoundly.
Alessandro BARILE
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source