Results 51 to 60 of about 2,873,192 (308)
Aspergillus fumigatus enhances elastase production in pseudomonas aeruginosaco-cultures [PDF]
, 2015 In the cystic fibrosis (CF) lung the presence of bacteria and fungi in the airways promotes an inflammatory response causing progressive lung damage, ultimately leading to high rates of morbidity and mortality.
Kerr, Stephen +6 more
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
The popular and the avant-garde: performance, incorporation and resistance [PDF]
, 2015 Many modernists in the late nineteenth century harboured a strong suspicion of the emerging mass culture produced for the working classes. Adopting a position similar to Matthew Arnold’s (2009) that culture was the speciality of a cultured few, and not ...
Price, Jason
core
Mass Rearing of the Greater Wax Moth, \u3ci\u3eGalleria Mellonella\u3c/i\u3e (Lepidoptera: Pyralidae), for Small-Scale Laboratory Studies [PDF]
, 2017 A technique was developed to mass rear the greater wax moth, Galleria mellonella, economically (ca. 0.2 cents per larva exclusive of 3-5 h of labor costs per week). Mortality in the egg and early larval stages was ca.
Coppel, H. C, Mohamed, M. A
core +2 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Literary Competitions Organised by the Ministry of Culture and Arts in 1949–1950 in the Light of Archive Records [PDF]
, 2016 The subject of this paper are these literary competitions organized by Ministry of Culture and Arts in the late 1940s and early 1950s. Analysys of the materials from archivesenabled to tackle the issues: these competitions are one of the many aspect of ...
Budrowska, Kamila
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Global Diffusion of Interactive Networks. The Impact of Culture [PDF]
, 1998 The Internet and other interactive networks are diffusing across the globe at rates that vary from country to country. Typically, economic and market structure variables are used to explain these differences.
Maitland, Carleen
core +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source