Results 101 to 110 of about 4,825,318 (291)

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li   +11 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Water diffusion in q-space imaging as a probe of cell local viscosity and anomalous diffusion in grey and white matter [PDF]

open access: yes, 2010
Extraction of accurate quantitative parameters to characterize water diffusion in complex porous media like brain tissue in neuroimaging is a challenging inverse problem, that depends on medium\\u27\u27s structural and geometrical factors [1,3].
Aubry, Florent   +8 more
core   +1 more source

Magnetic resonance imaging findings of xanthogranulomatous salpingo-oophoritis: A case report

open access: yesRadiology Case Reports
Xanthogranulomatous salpingo-oophoritis is an extremely rare disease that can be confused with adnexal malignancy. Few reports have described the diffusion-weighted imaging features of this disease.
Koichi Ito, MD   +12 more
doaj   +1 more source

Diffusion tensor imaging metrics in cystic intracranial mass lesions

open access: yesIndian Journal of Radiology and Imaging, 2017
Background and Purpose: Conventional MR does not always differentiate various cystic lesions of brain. Our purpose was to explore the utility of DTI in characterization & differentiation of intra cranial cystic mass lesions.
Amarnath Chellathurai   +3 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin   +8 more
wiley   +1 more source

Solid-state diffusion and NMR [PDF]

open access: yes, 2005
Diffusion in solids, which requires the presence of crystal defects or disorder, has both microscopic and macroscopic aspects. Nuclear magnetic resonance techniques provide access to microscopic diffusion parameters like atomic jump rates and activation ...
Heitjans, Paul   +2 more
core   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch   +5 more
wiley   +1 more source

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