Results 101 to 110 of about 26,221 (285)

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Invisible and ignored: lifting the lid on the problems of endemic zoonosez [PDF]

, 2015
No abstract ...
Halliday, Jo, Hampson, Katie, Lembo, Tiziana   +2 more
core  

Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis

Advanced Science, EarlyView.
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim, Ha Kyeong Lee, Zulfikar Azam, Jeong Uk Choi, Riajul Wahab, Na Kyeong Lee, Yoon Gun Ko, So‐Young Choi, Se‐Ra Lee, Wan Seob Shim, Taeeung Kim, In‐San Kim, Farzana Alam, Sang Yoon Kim, Seong Who Kim, Youngro Byun, Taslim A Al‐Hilal   +16 more
wiley   +1 more source

Perilaku Masyarakat Dalam Penanggulangan Penyakit Rabies Di Desa Kalasey Kecamatan Pineleng Kabupaten Minahasa [PDF]

, 2012
This study aimed to determine and assess the behavior of society in the prevention of rabies in the village District Kalasey Pineleng. The research method used was qualitative research by collecting data through interviews, observation and documentation.
Goni, J. H. (John), Pangemanan, M. C. (Meike)   +1 more
core  

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Painted Ferocity: The Social Behaviors of African Wild Dogs, Threats to Survival, and Resulting Conservation Initiatives [PDF]

, 2018
African Wild Dogs (Lycaon pictus) are an endangered species of canid from Sub-Saharan Africa. They are very social communal hunters, and are capable of chasing down prey for long stretches of time. Wild dogs benefit a savannah ecosystem by regulating the
Valdes, Alexis
core   +1 more source

Effective vaccination against rabies in puppies in rabies endemic regions. [PDF]

, 2015
In rabies endemic regions, a proportionally higher incidence of rabies is often reported in dogs younger than 12 months of age, which includes puppies less than 3 months of age; this presents a serious risk to public health.
AAHA [American Animal Hospital Association (AAHA) Canine Vaccination Task Force], AGHOMO, AWOYOMI, BELCHER, BELOTTO, BERAN, BERAN, BROOKS, BUTLER, CHAPPIUS, CHOMEL, CLEAVELAND, CLEAVELAND, CLIQUET, COLEMAN, DAVLIN, DAVLIN, DAY, DAY, DE BALOGH, DURR, DYCE, ESTRADA, EZEOKOLI, FLORES-IBARRA, GSELL, GUNATILAKE, HAMPSON, HAMPSON, HODGINS, KAARE, KASEMPIMOLPORN, KASEMPIMOLPORN, KAYALI, KITALA, KITALA, KNOBEL, KONGKAEW, LAPIZ, LEMBO, MALAGA, MATTER, MATTER, MCNABB, MITMOONPITAK, MITMOONPITAK, MORTERS, MORTERS, PUTRA, REECE, SCHNEIDER, SIEGRIST, SIEGRIST, TAIWO, TIZARD, TOUIHRI, VAN SITTERT, WHO, WIDDOWSON, WINDIYANINGSIH, WSAVA [Vaccination Guidelines Group (VGG) of the World Small Animal Veterinary Association (WSAVA)]   +60 more
core   +3 more sources

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Rabies in the Americas: 1998-2014.

PLoS Neglected Tropical Diseases, 2018
Through national efforts and regional cooperation under the umbrella of the Regional Program for the Elimination of Rabies, dog and human rabies have decreased significantly in Latin America and Caribbean (LAC) countries over the last three decades.
Mary Freire de Carvalho, Marco A N Vigilato, Julio A Pompei, Felipe Rocha, Alexandra Vokaty, Baldomero Molina-Flores, Ottorino Cosivi, Victor J Del Rio Vilas   +7 more
doaj   +1 more source