Results 211 to 220 of about 26,221 (285)

Vacancy defect‐induced electron homing breaks phosphodiester bonds for RNA depletion‐driven cancer therapy

open access: yesBMEMat, EarlyView.
Illustration of 5% S‐vacancy Bi2S3 mediated phosphodiester bonds cleavage in RNA of hepatocellular carcinoma cells, which suppressing ERI3 expression, inhibiting cell proliferation and promoting apoptosis. Abstract Genome‐wide hypertranscription is a hallmark of malignant progression.
Chuncheng Yang   +12 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

open access: yesBMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie   +12 more
wiley   +1 more source

A novel biomimetic liposome drug delivery system mediated by macrophage targeting for precision treatment of encephalitis

open access: yesBMEMat, EarlyView.
An advanced macrophage‐mediated biomimetic liposome (AC‐LP@RAW) that can penetrate the BBB and precisely target inflammatory sites in the deep brain was established in this study based on the unique immune homing property of macrophages, and showed a significantly improved delivery of curcumin to the brain.
Mengru Wu   +5 more
wiley   +1 more source

Rabies research in Uganda - A scoping review. [PDF]

open access: yesOne Health
Ghimire R   +9 more
europepmc   +1 more source

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

open access: yesBiotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya   +7 more
wiley   +1 more source

Cave dogs around major urban areas of Arequipa, Peru, threaten rabies elimination program. [PDF]

open access: yesFront Vet Sci
Castillo-Neyra R   +6 more
europepmc   +1 more source

SiC/Si ceramic hollow fibres: A new approach to Chlorella vulgaris biomass harvesting

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Abstract Efficient harvesting of microalgae is a critical challenge for the viability of biorefineries, requiring technologies that combine high selectivity, low cost, and scalability. The current work evaluated the performance of an asymmetric hollow fibre ceramic membrane (HF‐SiC70Si30), fabricated by phase inversion and sintered at 1250°C, in the ...
Erisson Paulo Borges Lopes   +4 more
wiley   +1 more source

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