Results 241 to 250 of about 26,221 (285)

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Advocating for incorporating public veterinary health care into human health systems. [PDF]

Front Vet Sci
Meythaler-Mullins L, Eia C, Lobdell AH, Frey DM.   +3 more
europepmc   +1 more source

A dendrimer enhanced CRISPR/Cas12a performance for the evaluation of acidogenic capacity in cariogenic bacteria

Interdisciplinary Medicine, EarlyView.
A CRISPR/Cas12a‐powered dendritic DNA nanostructure is assembled to create confined enzymatic microdomains, enabling ultrasensitive detection. Integrated into a paper‐based origami biosensor, it allows equipment‐free on‐site quantification of acidogenic pathogens for the early diagnosis of dental caries.
Yuan Zhang, Yining Zhao, Murtaza Sayed, Feng Chen, Juan Zhang   +4 more
wiley   +1 more source

Evidence of feline chaphamaparvovirus in dogs: molecular detection, genetic recombination, and tissue localization. [PDF]

BMC Vet Res
Piewbang C, Zahro AN, Poonsin P, Van Nguyen T, Punyathi P, Kasantikul T, Techangamsuwan S.   +6 more
europepmc   +1 more source

Wild Animal Suffering Is Not Intractable: A Precautionary Approach to Compassionate Intervention

Journal of Applied Philosophy, EarlyView.
ABSTRACT Wild animals suffer due to human activity, yet natural factors contribute far more significantly to their suffering. In light of this, some propose that we have a pro tanto obligation to intervene in ecosystems to improve wild animal welfare.
Tristan Katz
wiley   +1 more source

Knowledge and practices on dog bite management for rabies prevention in eThekwini, South Africa. [PDF]

J Public Health Afr
Ravhuhali K, Makamu M, Naidoo S, Zuma S, Mvelase S, Ntuli T, Shandu X, Myeni V, Buthelezi Z, Mlambo S, Hlanganyana P, Mbanjwa S, Thompson-Pillay J, Rambally SD, Phoswa M, Mchunu S, Zondi N, Gangat R, Phafane P, Zwane T, Netshivhumbe H, Ramutshila E, Mabona M, Ngidi V, Johnston L, Mhlongo B, Kuonza L.   +26 more
europepmc   +1 more source

Immunotherapy of Canine Leishmaniasis by Vaccination with Singlet Oxygen-Inactivated Leishmania infantum. [PDF]

Vaccines (Basel)
Manna L, Corso R, Kolli BK, Kim N, Chang KP.   +4 more
europepmc   +1 more source

Rabies control via co-creation: A model for sustainable one health interventions. [PDF]

PLoS Negl Trop Dis
Bor N, Njenga G, Slater A, Munywoki P, Chepyatich D, Owino D, Murungi MK, Muloi DM, Thomas LF.   +8 more
europepmc   +1 more source

Socioeconomic disparities and dog rabies: a retrospective analysis of high-spatial-resolution surveillance data from a Latin American city. [PDF]

Lancet Reg Health Am
Xie S, Shinnick J, Diaz EW, Zegarra E, Monroy Y, Recuenco SE, Castillo-Neyra R.   +6 more
europepmc   +1 more source