Results 231 to 240 of about 112,743 (311)

Design and construction of a pyrolysis unit - demonstrated in connection with gas chromatography-ion mobility spectrometry. [PDF]

HardwareX
Lippmann M, Hitzemann M, Eckhardt A, Röckrath D, Zimmermann S.   +4 more
europepmc   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Impact of the 2024 South Brazilian flood on obstetric and mental health outcomes in pregnant women. [PDF]

Arch Womens Ment Health
Skonieski LP, Giuberti P, Garcia MG, Baldi BB, Turra Berlaver S, Lodi MA, Machado GC, Motyczka E, Grassi-Oliveira R, Schreiner L, Viola TW.   +10 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Maternal stress shapes offspring innate immunity via milk leptin

Sommer* EL, Valtakari* NV, Holleman MJ, Peters CS, Linsen SA, Zegelaar M, Markus N, Mackaaij C, Thijssen S, Perdijk O, Witter L, Cleypool CG, Kooij MAvd.   +12 more
europepmc   +1 more source

The 'active reciprocity' ecosystem: senior cohousing as a determinant of social support and cognitive vitality independent of socioeconomic status. [PDF]

Front Public Health
Delgado-Losada ML, Sequeira-Villatoro B, Alcaide-Prieto C, Bouhaben J, Delgado-Ramos A.   +4 more
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Individual and environmental determinants of body mass index trajectories: results from a longitudinal study in Southern Sweden. [PDF]

BMC Public Health
Rebouillat P, Mattisson K, Gefenaite G, Östergren PO, Nilsson PM, Björk J.   +5 more
europepmc   +1 more source

Viscosity Characterization of PDMS and Its Influence on the Performance of a Torsional Vibration Viscous Damper Under Forced Hydrodynamic Loading. [PDF]

Materials (Basel)
Chmielowiec A, Michajłyszyn A, Gumieniak J, Woś S, Homik W, Antosz K.   +5 more
europepmc   +1 more source