Results 121 to 130 of about 11,063,016 (345)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
EClinicalMedicineSummary: Background: Limited data exists on how early-life weight changes relate to metabolic syndrome (MetS) risk in midlife. This study examines the association between long-term trajectories of body mass index (BMI), its variability, and MetS risk in
Tongshuai Guo +16 more
doaj +1 more source
Changes in Immigrants' Body Mass Index with Their Duration of Residence in Germany [PDF]
This paper investigates how immigrants' Body Mass Index (BMI) changes with increasing years since migration in Germany. The data are drawn from three waves (2002, 2004, and 2006) of the German Socio-Economic Panel Study (SOEP).
Monika Sander
core
The Star Formation Region NGC 6530: distance, ages and Initial Mass Function
, 2004 We present astrometry and $BVI$ photometry, down to $V\simeq22$, of the very young open cluster NGC6530, obtained from observations taken with the Wide Field Imager camera at the MPG/ESO 2.2 m Telescope. Both the $V$ vs. $B-V$ and the $V$ vs. $V-I$ color-
Alcala +48 more
core +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Anales de Pediatría (English Edition), 2018 Introduction: Body mass index-for age (BMI) and tri-ponderal mass index-for-age (TMI) values of healthy non-underweight, non-obese millennial children have not been reported until now. We aimed to obtain these values.
Antonio Carrascosa +6 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Realization of Zero-Refractive-Index Lens with Ultralow Spherical Aberration
, 2016 Optical complex materials offer unprecedented opportunity to engineer fundamental band dispersion which enables novel optoelectronic functionality and devices. Exploration of photonic Dirac cone at the center of momentum space has inspired an exceptional
Chang, Ming-Li +7 more
core +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source