Results 101 to 110 of about 2,182,808 (248)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Mass Media and Special Interest Groups [PDF]

open access: yes
Media revenues are an important determinant of media behavior. News coverage depends not only on the preferences of media consumers but also on the preferences of advertisers or subsidizing groups.
Maria Petrova
core  

Chasing Success: A Cultivated Reality [PDF]

open access: yes, 2018
George Gerbner’s cultivation theory claims that people who consume heavy amounts of media are more likely to be influenced by those messages to believe the media reality as opposed to actual reality.
Bevillard, Anastasia
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Perception of Social and Behaviour Change Communication Media in Cross River State, Nigeria [PDF]

open access: yes, 2016
In the wake of increased interventions into health and social problems arising from various behaviours in Cross River State, this paper is set to ascertain the most effective media that can be utilized for effective communication.
Iyorza, Stanislaus
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Synonymic Representation of “Islamic World” in American Mass Media [PDF]

open access: yes, 2011
У статті представлено аналіз синонімічного ряду «Ісламської картини світу» у сучасній американській ...
Семенюк, І. С.   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Mass Media and Polarisation Processes in the Bounded Confidence Model of Opinion Dynamics [PDF]

open access: yes
This paper presents a social simulation in which we add an additional layer of mass media communication to the social network \'bounded confidence\' model of Deffuant et al (2000).
Gary Mckeown, Noel Sheehy
core  

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