Results 71 to 80 of about 1,144,139 (258)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Embracing Immersive Journalism: Adoption and Integration by News Media Producers

Journalism and Media
Immersive journalism, utilizing virtual reality (VR) and augmented reality (AR) technologies, offers a transformative approach to storytelling by creating deeply engaging news experiences.
Ioanna Georgia Eskiadi, Nikolaos Panagiotou   +1 more
doaj   +1 more source

Branded Media Text as Communicative-integration Model of Interaction with Audience

SHS Web of Conferences, 2018
The development dynamics of information and communication technologies (ICTs), especially network providing expansion of interpersonal and mass communications, radically changes the existing practice of distribution and representation of a media product.
Urazova Svetlana, Volkova Irina, Baranova Ekaterina, Druzhinin Andrey, Ulyura Anastasia   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Gamified Engagement for Data Crowdsourcing and AI Literacy: An Investigation in Affective Communication Through Speech Emotion Recognition

Societies
This research investigates the utilization of entertainment approaches, such as serious games and gamification technologies, to address various challenges and implement targeted tasks.
Eleni Siamtanidou, Lazaros Vrysis, Nikolaos Vryzas, Charalampos A. Dimoulas   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Films as a Tool for Climate Education: A Quasi-Experimental Intervention amongst Middle School Children from the Indian Himalayan Region

Australian Journal of Environmental Education
The study investigates the potential role that films may play in raising awareness and motivation to act for climate change mitigation. The study was conducted amongst middle school children based in Kangra District of Himachal Pradesh, India (n = 135 ...
Krishna Kharwar, Pradeep Nair, Deepak Kumar Vaishnav, Akriti Bansal, Lauren Dagon Amoss   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Out-of-pocket expenditure on medicine for chronic patients and its economic impact on Indian households: a systematic review and meta-analysis

Frontiers in Medicine
BackgroundOut-of-pocket expenditure (OOPE) on medicines constitutes a substantial component of healthcare spending in India, particularly among patients with chronic diseases requiring continuous treatment.
Deepak Kumar Vaishnav, Deepak Kumar Vaishnav, A. Venkat Raman, A. Venkat Raman, Akriti Bansal, Akriti Bansal, Pradeep Nair, Pradeep Nair, Krishna Kharwar, Krishna Kharwar   +9 more
doaj   +1 more source