Results 151 to 160 of about 4,338,110 (346)

Testing Gravity Theory With Extreme Mass-Ratio Inspirals: Recent Progress

open access: yesProceedings, 2019
A compact object captured by a supermassive black hole, named as extreme-mass-ratioinspiral (EMRI), is one of the most important gravitational wave sources for low-frequencyinterferometers such as LISA, Taiji, and TianQin. EMRIs can be used to accurately
Shucheng Yang   +3 more
doaj   +1 more source

The Impact of Diet and Physical Activity on Fat-to-Lean Mass Ratio. [PDF]

open access: yesNutrients, 2023
Padua E   +9 more
europepmc   +1 more source

Simulating extreme-mass-ratio systems in full general relativity

open access: yes, 2013
We introduce a new method for numerically evolving the full Einstein field equations in situations where the spacetime is dominated by a known background solution.
East, William E., Pretorius, Frans
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

The scatter in mass-to-luminosity ratios [PDF]

open access: yesSymposium - International Astronomical Union, 1978
Mass-to-luminosity ratios of systems of galaxies as derived by different authors have a large scatter from ~ 10 to ~ 200. the observational data used by different authors differ only slightly, so the differences should lie in the treatment of the data. We have found that in most cases < M/L > differences can be explained in the following ways.
openaire   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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