Results 141 to 150 of about 975,461 (302)

Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry

, 2009
Hepatotoxic pyrrolizidine alkaloid (HPA)-containing plants have always been a threat to human and livestock health worldwide. Adonifoline, a main HPA in Senecio scandens Buch.-Ham. ex D.
Wang, C.-H., Xiong, A., Zhang, F., Han, H., He, Y.Q., Wang, J., Wang, Z., Yang, L., Bligh, S.W.A.   +8 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism

, 2008
The creation of the Commission, which was established by House Resolution 1, implements a key recommendation of the independent, bipartisan 9/11 Commission to address the grave threat that the proliferation of weapons of mass destruction poses to our ...
Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism (U.S.)
core  

Sequencing and Identification of Endogenous Neuropeptides with Matrix-Enhanced Secondary Ion Mass Spectrometry Tandem Mass Spectrometry

, 2017
Matrix-enhanced secondary ion mass spectrometry (ME-SIMS) has overcome one of the biggest disadvantages of SIMS analysis by providing the ability to detect intact biomolecules at high spatial resolution. By increasing ionization efficiency and minimizing
Nina Ogrinc Potočnik, Heeren, Ron M. A., Gregory L. Fisher, Arnoud Prop, Fisher, Gregory L., Prop, Arnoud, Potocnik, Nina Ogrinc, Ron M. A. Heeren   +7 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Fragmentation and Dijet Mass Resolution

, 2004
At the LHC the overlap of minimum bias events and the jet energy deposits in a calorimeter causes a degradation in the dijet mass resolution. Guided by QCD, a judicious set of cuts can be developed to mitigate this degradation.
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Ultralong transients enhance sensitivity and resolution in Orbitrap-based single-ion mass spectrometry [PDF]

Orbitrap-based charge detection mass spectrometry utilizes single-molecule sensitivity to enable mass analysis of even highly heterogeneous, high-mass macromolecular assemblies.
Rolland, Amber D, Heck, Albert J R, Nagornov, Konstantin O, Deslignière, Evolène, Fort, Kyle L, Ebberink, Eduard H T M, Yin, Victor C, Barendregt, Arjan, Wörner, Tobias P, Tsybin, Yury O, Kozhinov, Anton N, Makarov, Alexander A   +11 more
core  

Imaging Single-Chain Nanoparticle Folding via High-Resolution Mass Spectrometry

, 2016
Herein, we introduce the first approach to map single-chain nanoparticle (SCNP) folding via high-resolution electrospray ionization mass spectrometry (ESI MS) coupled with size exclusion chromatography.
Christopher Barner-Kowollik, Hannah Rothfuss (3602201), Jan Steinkoenig, Bryan T. Tuten (1560751), Steinkoenig, Jan, Lauer, Andrea, Tuten, Bryan T., Andrea Lauer, Jan Steinkoenig (3602198), Bryan T. Tuten, Rothfuss, Hannah, Christopher Barner-Kowollik (1412413), Andrea Lauer (1442593), Hannah Rothfuss, Barner-Kowollik, Christopher   +14 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source