Results 121 to 130 of about 5,476,582 (407)

Merging clinical chemistry biomarker data with a COPD database - building a clinical infrastructure for proteomic studies

open access: yesProteome Science, 2017
Background Data from biological samples and medical evaluations plays an essential part in clinical decision making. This data is equally important in clinical studies and it is critical to have an infrastructure that ensures that its quality is ...
Jonatan Eriksson   +10 more
doaj   +1 more source

Variational autoencoders for tissue heterogeneity exploration from (almost) no preprocessed mass spectrometry imaging data [PDF]

open access: yesarXiv, 2017
The paper presents the application of Variational Autoencoders (VAE) for data dimensionality reduction and explorative analysis of mass spectrometry imaging data (MSI). The results confirm that VAEs are capable of detecting the patterns associated with the different tissue sub-types with performance than standard approaches.
arxiv  

Application of tandem two-dimensional mass spectrometry for top-down deep sequencing of calmodulin [PDF]

open access: yes, 2018
Two-dimensional mass spectrometry (2DMS) involves simultaneous acquisition of the fragmentation patterns of all the analytes in a mixture by correlating their precursor and fragment ions by modulating precursor ions systematically through a fragmentation
Barrow, Mark P.   +5 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Spatial Metabolomics Approach Reveals the Pharmacodynamic Substances and Mechanism of Panax ginseng in Alzheimer’s Disease Mice

open access: yesZhipu Xuebao
Panax ginseng, a venerable herb in traditional Chinese medicine, boasts a rich history of usage in the treatment of dementia, particularly in its various manifestations.
Yu-ting FAN   +5 more
doaj   +1 more source

Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry [PDF]

open access: yes, 2005
In a growing number of laboratories the technique of liquid chromatography-tandem mass spectrometry is used for the quantification of cyclosporin A in whole blood, employing cyclosporin D as the internal standard. Cyclosporin A is extensively metabolized
Spöhrer, Ute, Vogeser, Michael
core   +1 more source

Ambient Ionization Mass Spectrometry: Recent Developments and Applications.

open access: yesAnalytical Chemistry, 2019
The early 2000s brought a new age in the field of mass spectrometry (MS) with the introduction of ambient ionization MS techniques. As defined by one of its early visionaries, Prof. R.
Clara L. Feider   +3 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

On-line Analysis of the Electrochemical Oxidation of Dopamine in High Concentration Phosphate Buffer Solution by Electrochemical Mass Spectrometry [PDF]

open access: yesZhipu Xuebao
Electrochemical mass spectrometry is an important technique for studying the mechanism of electrochemical reactions. Mass spectrometry has the advantages of high detection sensitivity, high detection throughput and high specificity, which enables ...
LIN Jia-mei   +6 more
doaj   +1 more source

A Cyclic Ion Mobility-Mass Spectrometry System.

open access: yesAnalytical Chemistry, 2019
Improvements in the performance and availability of commercial instrumentation have made ion mobility-mass spectrometry (IM-MS) an increasingly popular approach for the structural analysis of ionic species as well as for separation of complex mixtures ...
K. Giles   +6 more
semanticscholar   +1 more source

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