Results 131 to 140 of about 1,203,401 (307)

Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson’s disease

npj Parkinson's Disease
L-DOPA-induced dyskinesia (LID) is a significant and treatment-limiting complication in Parkinson’s disease (PD) therapy, yet its mechanisms remain poorly understood.
Ibrahim Kaya, Theodosia Vallianatou, Anna Nilsson, Patrik Bjärterot, Reza Shariatgorji, Per Svenningsson, Erwan Bezard, Per E. Andrén   +7 more
doaj   +1 more source

Clinical evaluation of advanced MALDI-TOF MS for carbapenemase subtyping in Gram-negative isolates

Journal of Clinical Microbiology
The spread of carbapenemase-producing Enterobacterales (CPE) is emerging as a significant clinical concern in tertiary hospitals and, in particular, long-term care facilities with deficiencies in infection control. This study aims to evaluate an advanced
Dong Huey Cheon, Heejung Jang, Yoon Kyung Choi, Won Seok Oh, Seohyun Hwang, Ju-Ri Park, Hyojin Kim, Yoonha Park, Saeyoung Lee, Won Suk Yang, Min Jin Kim, Sun Hwa Lee, Je-Hyun Baek   +12 more
doaj   +1 more source

Analyses of moisture in polymers and composites [PDF]

A suitable method for the direct measurement of moisture concentrations after humidity/thermal exposure on state of the art epoxy and polyimide resins and their graphite and glass fiber reinforcements was investigated.
Ryan, L. E., Vaughan, R. W.
core   +1 more source

An Evaluation of Lysyl Oxidase–Derived Cross-Linking in Keratoconus by Liquid Chromatography/Mass Spectrometry [PDF]

, 2016
Anna Takaoka, Natasha Babar, Julia Hogan, Mijung Kim, Marianne O. Price, Francis W. Price, Stephen L. Trokel, David C. Paik   +7 more
openalex   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

One section, two worlds: single-cell integration of MALDI-MSI and spatial transcriptomics on the same single tissue section

Scientific Reports
Understanding tissue complexity requires spatially resolved multi-omics data at single-cell resolution. Here, we present a workflow integrating high-resolution matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) with Xenium ...
Tim F. E. Hendriks, Gert B. Eijkel, Theodoros Visvikis, Benjamin Balluff, Ron M. A. Heeren, Eva Cuypers   +5 more
doaj   +1 more source

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source

Chemical ionization tandem mass spectrometer for the in situ measurement of methyl hydrogen peroxide [PDF]

, 2010
A new approach for measuring gas-phase methyl hydrogen peroxide [(MHP) CH_3OOH] utilizing chemical ionization mass spectrometry is presented. Tandem mass spectrometry is used to avoid mass interferences that hindered previous attempts to measure ...
Crounse, John D., McCabe, David C., St. Clair, Jason M., Steiner, Urs, Wennberg, Paul O.   +4 more
core  

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Deep MALDI-MS spatial omics guided by quantum cascade laser mid-infrared imaging microscopy

Nature Communications
In spatial’omics, highly confident molecular identifications are indispensable for the investigation of complex biology and for spatial biomarker discovery.
Lars Gruber, Stefan Schmidt, Thomas Enzlein, Huong Giang Vo, Tobias Bausbacher, James Lucas Cairns, Yasemin Ucal, Florian Keller, Martina Kerndl, Denis Abu Sammour, Omar Sharif, Gernot Schabbauer, Rüdiger Rudolf, Matthias Eckhardt, Stefania Alexandra Iakab, Laura Bindila, Carsten Hopf   +16 more
doaj   +1 more source