Results 91 to 100 of about 452,890 (342)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Incorporation of substrate blocks into mass transport deposits: Insights from subsurface and outcrop studies

The Depositional Record
Mass movements are common on the continental slope, affecting not only the subsequent sea floor morphology but often substantially modifying the underlying deposits.
Victoria Valdez Buso, Ben Kneller, Vanessa daSilva Reis Assis, Fernando Farias Vesely, Juan Pablo Milana   +4 more
doaj   +1 more source

Mass wasting triggered by seasonal CO₂ sublimation under Martian atmospheric conditions: Laboratory experiments [PDF]

, 2016
Sublimation is a recognized process by which planetary landscapes can be modified. However, interpretation of whether sublimation is involved in downslope movements on Mars and other bodies is restricted by a lack of empirical data to constrain this ...
Adam Barnes, Bart, Brusnikin, Cedillo-Flores, Conway, Conway, DiBiase, Diniega, Diniega, Dundas, Dundas, Gardin, Hansen, Harrison, Hess, Hugenholtz, John C. Dixon, Kieffer, Kreslavsky, Krohn, Lague, Landis, Lanza, Malin, Malin, Mangold, Manish R. Patel, Matthew E. Sylvest, McEwen, McEwen, Pasquon, Pilorget, Piqueux, Reiss, Reiss, Schorghofer, Scully, Sullivan, Sullivan, Susan J. Conway, Vincendon   +40 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Analysis of Injectivity Decline in some Deepwater Water Injectors [PDF]

, 2013
Imperial Users ...
Dambani, Samuel, Dambani, Samuel
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Mass wasting at the base of the South central Chilean continental margin: the Reloca Slide [PDF]

, 2009
Offshore south central Chile (35° S–42° S), the morphology of the lowermost continental slope and trench floor witnesses a voluminous submarine mass-wasting event.
Behrmann, Jan Hinrich, Bialas, Jörg, Klaeschen, Dirk, Völker, David, Weinrebe, Reimer Wilhelm   +4 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The Controlling Factors and Prediction of Deep-Water Mass Transport Deposits in the Pliocene Qiongdongnan Basin, South China Sea

Journal of Marine Science and Engineering
Large-scaled submarine slides or mass transport deposits (MTDs) widely occurred in the Pliocene Qiongdongnan Basin, South China Sea. The good seismic mapping and distinctive topography, as well as the along-striking variation in sediment supply, make it ...
Jiawang Ge, Xiaoming Zhao, Qi Fan, Weixin Pang, Chong Yue, Yueyao Chen   +5 more
doaj   +1 more source