Results 71 to 80 of about 452,890 (342)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Hydrodynamic Constraints on Ore Formation by Basin‐Scale Fluid Flow at Continental Margins: Modelling Zn Metallogenesis in the Devonian Selwyn Basin

Geochemistry, Geophysics, Geosystems, 2021
The clastic‐dominant (CD‐type) deposits that are contained within sedimentary basins are major resources of Zn, Pb and Ag, but their formation by basin‐scale hydrothermal mass and energy transport processes is still poorly understood.
Alejandro Rodríguez, Philipp Weis, Joseph M. Magnall, Sarah A. Gleeson   +3 more
doaj   +1 more source

BOTANI: High-fidelity multiphysics model for boron chemistry in CRUD deposits

Nuclear Engineering and Technology, 2021
We develop a new high-fidelity multiphysics model to simulate boron chemistry in the porous Chalk River Unidentified Deposit (CRUD) deposits. Heat transfer, capillary flow, solute transport, and chemical reactions are fully coupled.
Seungjin Seo, Byunggi Park, Sung Joong Kim, Ho Cheol Shin, Seo Jeong Lee, Minho Lee, Sungyeol Choi   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Application of seismic stratigraphy in reservoir characterisation: a case study of the passive margin deposits of the northern Orange Basin, South Africa

Journal of Petroleum Exploration and Production Technology, 2020
The Barremian-Cenozoic depositional sequences in the northern Orange Basin, SW, South Africa, were investigated using the principles of seismic stratigraphy to understand the interplay of tectonics and sedimentary processes in the distribution of ...
Chris Adesola Samakinde, Jan Marinus Van Bever Donker, Ray Durrheim, Musa Manzi   +3 more
doaj   +1 more source

Tsunamis From Submarine Collapses Along the Eastern Slope of the Gela Basin (Strait of Sicily)

Frontiers in Earth Science, 2021
Geophysical surveys in the eastern slope of the Gela Basin (Strait of Sicily, central Mediterranean) contributed to the identification of several episodes of sediment mass transport, recorded by scars and deposits of various dimensions within the ...
Filippo Zaniboni, Filippo Zaniboni, Gianluca Pagnoni, Maria Ausilia Paparo, Tugdual Gauchery, Tugdual Gauchery, Marzia Rovere, Andrea Argnani, Alberto Armigliato, Stefano Tinti   +9 more
doaj   +1 more source

Overview of technologies for constructing the facilities at the Dniester pumped storage power station [PDF]

, 2019
Purpose. Perform an overview of the construction technologies and substantiate the effectiveness of the Ukrainian experience in building a pumped storage power station (PSPS) on the Dniester River in difficult engineering-geological conditions with the ...
Horbatiuk, Yu, Parinov, V, Petrenko, V, Radkevych, A, Tiutkin, O   +4 more
core   +1 more source

Block Generation, Deformation, and Interaction of Mass‐Transport Deposits With the Seafloor

Submarine Landslides, 2019
17 Mass transport processes are notorious for their ability to carry large blocks or mega 18 clasts, to deform sediments, and to interact with the seafloor through deformation and/or 19 erosion of the substrate.
Matheus S. Sobiesiak, Victoria Buso, B. Kneller, G. Alsop, J. Milana   +4 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

New perspectives on deep-water sandstones: Implications

Petroleum Exploration and Development, 2013
The emerging new concepts of sandy mass-transport deposits (SMTD) and bottom-current reworked sands (BCRS) have made a big impact on conventional turbidite concepts.
G. Shanmugam
doaj   +1 more source