Results 211 to 220 of about 5,219,266 (280)

When Mechanics Rewrites Chemistry: Divergent Pathways of Hardening and Softening in High Strength Al‐Alloys

open access: yesAdvanced Science, EarlyView.
Mechanics reshapes chemistry: plastic flow actively governs two divergent, atomic‐scale mechanochemical pathways that tailor strain localization and ductility in high‐strength 7xxx Al alloys. Rather than relying on static structures, deformation dynamically reinforces the solution‐treated state via clustering, yet destabilizes the peak‐aged condition ...
Huan Zhao   +9 more
wiley   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

open access: yesAdvanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan   +7 more
wiley   +1 more source

Arthropod‐Inspired Miniature Modular Vibration Direct‐Drive Robot With Untethered Locomotion

open access: yesAdvanced Science, EarlyView.
This work presents an arthropod‐inspired untethered miniature modular vibration direct‐drive robot. By utilizing standardized driving units and nested locking interfaces, on‐demand reconfiguration into quadruped, hexapod, octopod, and circular morphologies is achieved.
Shijing Zhang   +4 more
wiley   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

open access: yesAdvanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang   +20 more
wiley   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

open access: yesAdvanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li   +6 more
wiley   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

open access: yesAdvanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou   +21 more
wiley   +1 more source

Solvent‐Free Synthesis of Ultrabright Carbon Dots With Near‐Unity Quantum Yield for High‐Performance Light‐Emitting Diodes

open access: yesAdvanced Science, EarlyView.
A rational, solvent‐free synthesis utilizing 2,6‐diaminonaphthalene produces ultrabright green‐emissive carbon dots. Regulated by a self‐limiting oxidative capping mechanism, excitons undergo ultrafast intra‐particle funneling from the nitrogen‐doped carbon core to emissive surface traps.
Hyeonjin Park   +8 more
wiley   +1 more source

Wood Carbon Sponge/SiO2 Aerogel Composites with Anisotropic Broadband Microwave Absorption, Elastic Resilience, and Thermal Insulation

open access: yesAdvanced Science, EarlyView.
Anisotropic wood carbon sponge/SiO2 aerogel composites are constructed, revealing a robust direction‐dependent permittivity ordering (tangential > radial > axial). The radial direction delivers an ultra‐broadband effective absorption bandwidth of 11.6 GHz at only 4.95 mm, while the tangential direction offers superior compressibility and thermal ...
Shuo Sun   +7 more
wiley   +1 more source

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