Results 31 to 40 of about 61,616 (223)

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Residual breast tissue after robot-assisted nipple sparing mastectomy

Breast, 2021
Introduction: While the long-term oncologic safety of robot-assisted nipple sparing mastectomy (RNSM) remains to be elucidated, histologically detected residual breast tissue (RBT) can be a surrogate for oncologically sound mastectomy.
Ko Un Park, MD, Gary H. Tozbikian, MD, David Ferry, RNFA, Allan Tsung, MD, Mathew Chetta, MD, Steven Schulz, MD, Roman Skoracki, MD   +6 more
doaj   +1 more source

Gephyrin Neurological Autoimmunity

Annals of Neurology, EarlyView.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Sexuality, depression and body image after breast reconstruction

Clinics
OBJECTIVES: To evaluate the impact of breast reconstruction after mastectomy on sexual function, body image, and depression. METHODS: This cross-sectional, comparative, controlled study was conducted with 90 women between 18 and 65 years of age who had ...
Silvania de Cassia Vieira Archangelo, Miguel Sabino Neto, Daniela Francescato Veiga, Elvio Bueno Garcia, Lydia Masako Ferreira   +4 more
doaj   +1 more source

A Strategic Approach to Nipple-sparing Mastectomy Reconstruction with a Wide-based Inframammary Fold Flap

Plastic and Reconstructive Surgery, Global Open, 2020
Summary:. The single biggest advancement in the aesthetic outcome of breast reconstruction following mastectomy has been the contribution of nipple-sparing mastectomy. By preserving the nipple–areolar complex, patients do not experience the same sense of
Anamaria Parus, BS, Mark L. Venturi, MD, FACS   +1 more
doaj   +1 more source

Depression in breast cancer patients who have undergone mastectomy: A national cohort study.

PLoS ONE, 2017
ObjectiveThe objective of this study was to compare the incidence of post-operative depression in breast cancer patients who have undergone mastectomy with the incidence of post-operative depression in non-breast cancer participants (controls ...
Min-Su Kim, So Young Kim, Jin-Hwan Kim, Bumjung Park, Hyo Geun Choi   +4 more
doaj   +1 more source

A Single-Center Retrospective Analysis of Local and Distant Relapse of Breast Cancer Following Immediate Breast Reconstruction According to Molecular Subtypes

Frontiers in Oncology, 2022
PurposeConcerns have been raised about the oncologic safety of immediate breast reconstruction (IBR) following mastectomy for breast cancer. This study aimed to evaluate locoregional recurrence (LRR) and distant metastasis (DM) of breast cancer according
Chunyong Han, Chunyong Han, Chunyong Han, Chunyong Han, Chunyong Han, Xuehui Zhang, Xuehui Zhang, Xuehui Zhang, Xuehui Zhang, Xuehui Zhang, Jingyan Sun, Jingyan Sun, Jingyan Sun, Jingyan Sun, Jingyan Sun, Jing Liu, Jing Liu, Jing Liu, Jing Liu, Jing Liu, Shanshan He, Shanshan He, Shanshan He, Shanshan He, Shanshan He, Jian Yin, Jian Yin, Jian Yin, Jian Yin, Jian Yin   +29 more
doaj   +1 more source

Effectiveness of Educational Guidelines on Post Mastectomy Women's Knowledge, Practices, and Psychological Stress Regarding External Breast Prosthesis [PDF]

Egyptian Journal of Health Care
The knowledge that they have breast cancer and the loss of their physical attractiveness are two major concerns that women who have had a mastectomy for the disease contend with.
Badr Ibrahim Ahmed Abdou Abd El Rahman, Ebtesam Aly Abd el Fatah Aly, Mona Gamal Abd Elnaser Ahmed Elnabawey, Manal Ibrahem Abd El Fatah Yassen   +3 more
doaj   +1 more source

Maximizing Neurovascular Outcomes of Facial Transplantation: A Comprehensive Review

Clinical Anatomy, EarlyView.
ABSTRACT Facial transplantation is a division of reconstructive surgery which aims to improve the function and appearance of a face that has endured severe disfigurement. Currently, the face transplant procedure uses allogenic tissue, harvested from a brain‐dead donor, to replace damaged facial components.
Olivia A. James, Faye Bennett
wiley   +1 more source

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Usa Boonyuen, Sirinyatorn Talukam, Beatriz Aira C. Jacob, Wayu Matphong, Kamonwan Chamchoy, Onrapak Reamtong, Nuntana Meesiripan, Junya Yamagishi, Matthew Phanchana, Chayanoot Rattadilok   +9 more
wiley   +1 more source