Results 231 to 240 of about 178,319,880 (288)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

A longitudinal core curriculum to strengthen interprofessional competencies in German undergraduate nursing education: a mixed methods study. [PDF]

BMC Med Educ
Lehnen T, Lueth F, Wolter L, Busch J, Püschel L, Leimer M, Rahn AC, Balzer K, von Gahlen-Hoops W.   +8 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A case report of shingles and subsequent cardiac ischaemia in a young male. [PDF]

Eur Heart J Case Rep
Eisendrath K, Horne S, Edmondson L, West A, Robertson D.   +4 more
europepmc   +1 more source

Temporal heterogeneity shapes diffusion dynamics in complex networks. [PDF]

Nat Commun
Luo C, Lambiotte R, Ji P.
europepmc   +1 more source

Master's programs in vaccinology in Spain: a nationwide systematic environmental scan and a Delphi-informed core curriculum proposal. [PDF]

Front Public Health
Fernández-Chávez AC, Aranaz Andrés JM, Sánchez-Carmona DL, Hernán-García C, Franco FJ.   +4 more
europepmc   +1 more source

Acceptability and factors influencing human milk banking among healthcare professionals in eastern Ethiopia: a mixed methods study. [PDF]

Int Breastfeed J
Abadir A, Girma S, Meseret F, Hussen H, Keneni M, Desalew A.   +5 more
europepmc   +1 more source

The Case for Master Protocols for Rare Neurological Diseases. [PDF]

Ann Neurol
Vermilion J, Paganoni S, Plotkin SR, Quintana M, Calvert SB, Whiteman IT, Wang RY, Moore N, Augustine EF.   +8 more
europepmc   +1 more source