Results 71 to 80 of about 1,879,889 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Environmental implications of phytoextraction for mercury and gold : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Earth Science [PDF]

, 2000
The overall objective of this study was to investigate how plants could be used to harvest gold (phytomining) and at the same time remove mercury (phytoremediation) from auriferous mercury-contaminated soils. This study was undertaken to find appropriate
Msuya, Fletcher Abduel Msami
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A statistical analysis of Chinese traditional sports science master′s degree thesis

上海师范大学学报. 自然科学版, 2013
Through a statistical analysis of 367 sports science master′s degree thesis on Chinese traditional sport in the past five years,some conclusions can be drawn that the traditional national sports master's degree thesis should expand the theoretical depth;
SHEN Wenjuan, GAO Mufeng, LUAN Leizu
doaj  

Chemistry at the ICBC: The Institute of Chemistry and Biological Chemistry in Wädenswil Chemie studieren am Institut für Chemie und Biologische Chemie (ICBC) der Zürcher Hochschule für Angewandte Wissenschaften in Wädenswil

CHIMIA, 2008
The newly established Institute of Chemistry and Biological Chemistry (ICBC) at the Department of Life Sciences and Facility Management of the Zurich University of Applied Sciences offers Bachelor degrees in chemistry and biological chemistry ...
Christian Hinderling
doaj   +1 more source

Some experiences from an optics master of science degree [PDF]

SPIE Proceedings, 2000
About forty university graduates have completed their specialized studies in Optics. These specialized studies enable their successful development in their professional tasks in national Cuban institutions. In the conception of the Optics Master of Science degree plan, professional improvement is considered regarding the accumulated experience, the ...
Angel G. Augier Calderin, Adriana Mavilio, Agueda Garcia   +2 more
openaire   +1 more source

The usefulness of personality questionnaires in officer selection and training : a paper submitted in fulfilment of the Master of Science degree [PDF]

, 1999
The aim of the current research was to assess whether the Revised Eysenck Personality Questionnaire (EPQ-R) and the Gordon Personal Profile-Inventory (GPP-I) could predict future behaviour in a sample of NZ Army officers and officer cadets.
Bowden, Charlotte
core