Results 181 to 190 of about 2,055,844 (275)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

open access: yesAdvanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni   +17 more
wiley   +1 more source

Future climate projections. Morrow County : June 2023

open access: yes
In this report, we present climate projections for Morrow County that are relevant to specified natural hazards for the 2020s (2010–2039) and 2050s (2040–2069) relative to the 1971–2000 historical baseline.
Fleishman, Erica   +3 more
core  

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

open access: yesAdvanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao   +5 more
wiley   +1 more source

Leverage Points for Wellbeing and Achievement in Vocational Education: A Network Analysis of Psychological Factors Across Gender and Majors. [PDF]

open access: yesBehav Sci (Basel)
Likhanov M   +7 more
europepmc   +1 more source

Anchor Engineering of Hole‐Selective Enamine‐Based Self‐Assembling Monolayers for Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
This work presents novel enamine‐based self‐assembling monolayers with engineered anchoring groups as hole‐selective contacts for inverted perovskite solar cells. The conjugated molecular design suppresses interfacial defects, optimizes charge extraction, and prevents aggregation.
Deimante Krisiune   +11 more
wiley   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

open access: yesAdvanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du   +15 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

open access: yesAdvanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu   +17 more
wiley   +1 more source

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