Results 101 to 110 of about 2,248 (205)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Dual Quantum Dot Molecular FRET Probes for Picomolar DNA Hexaplexing

Small Methods, EarlyView.
Multiplexed quantification of six different DNA targets from a single 200 µL sample at picomolar concentrations was accomplished by spectrotemporal detection of time‐resolved FRET from a single Tb‐complex donor to two quantum dot acceptors using one‐color excitation and two‐color detection.
Ruifang Su, Federico Pini, Nour Fayad, Kimihiro Susumu, Marta M. Natile, Igor L. Medintz, Thibault Gallavardin, Thomas J. Sørensen, Niko Hildebrandt   +8 more
wiley   +1 more source

Matérias-primas para biodiesel

Agropecuária Catarinense, 2020
Adriano Martinho de Souza, Alvadi Antonio Balbinot Junior, Rogério Luiz Backes, José Alfredo da Fonseca, Gilson José Marcinichen Gallotti, Ana Lúcia Hanisch, Gilcimar Adriano Vogt   +6 more
doaj  

Translucency and mechanical behavior of  partially stabilized monolithic zirconia after staining, finishing procedures and artificial aging. [PDF]

Sci Rep, 2022
da Silva AO, Fiorin L, Faria ACL, Ribeiro RF, Rodrigues RCS.   +4 more
europepmc   +1 more source

‘Enthusiasts’ and ‘Fanatics’: The Decembrists as a Case Study in French Influence on Russian Culture, Emotions and Thought

History, EarlyView.
Abstract Participants in Russia's 1825 Decembrist uprising against the Tsarist regime were, quite literally, a case study in French cultural influence upon Russia. This is particularly true as it relates to Russia's emotional cultures. Although this has not, traditionally, been the primary focus of historical analysis of this event (in Soviet or ...
ADAM COKER
wiley   +1 more source

Contribución de la vigilancia Tecnológica a la formulación de Proyectos de Nuevas Tecnologías para la producción de biocombustibles

Revista Centro Azúcar, 2008
Se desarrolla una estrategia para la asimilación de tecnología, a través de la formulación de proyectos de investigación, para el desarrollo de Nuevas Tecnologías de obtención de biocombustibles, para lo cual se utilizó la Vigilancia Tecnológica como ...
Erenio González Suárez, Meilyn González Cortés, Leyanis Mesa Garriga, Gretel Villanueva Ramos, Silvia Daniela Romano, Romel García Alaric   +5 more
doaj  

The Training Complex: Shattering of the Coniunctio, Boundary Violation, and Sibling Turbulence on the Horizontal Plane

Journal of Analytical Psychology, EarlyView.
Abstract This paper explores what is happening, for a trainee, when an ethical boundary violation occurs by the analyst with a fellow peer in training. I am approaching this through the Jungian concept of the alchemical vas as I attempt to make meaning of a catastrophic collapse of the analytic work.
Anne Marie Allen
wiley   +1 more source

COEFICIENTES DE DIGESTIBILIDAD APARENTE DE Thitonia diversifolia Y Cratylia argentea EN CACHAMA BLANCA Y EFECTOS SOBRE LAS VELLOSIDADES INTESTINALES

Revista U.D.C.A Actualidad & Divulgación Científica, 2017
En atención a identificar nuevas materias primas fuentes de proteína que no compitan con la alimentación humana, se determinaron los coeficientes de digestibilidad aparente de la proteína (CDA-P), materia seca (CDA-MS) y energía (CDA-E), de botón de oro ...
Luis Fernando Puerta Rico, José Jaime García González, Jaime Eduardo Parra Suescún, Sandra Clemencia Pardo Carrasco   +3 more
doaj  

Adipokines in Obese Asthma: A Complex Relationship Influenced More by Sex, Weight, and Oral Steroid Treatment Than Disease Severity

Allergy, EarlyView.
Adipokine secretion from adipose tissue may be involved in obesity‐related asthma, but it is unknown how adipokine levels relate to asthma characteristics. Plasma adipokines were measured in well‐characterized lean, overweight or obese patients with mild‐to‐moderate or severe asthma.
Lars I. Andersson, Maciej Kupczyk, Barbro Dahlén, Kenji Izuhara, Mina Gaga, Nikos M. Siafakas, Alberto Papi, Bianca Beghe, Guy Joos, Klaus F. Rabe, Elisabeth H. Bel, Sebastian L. Johnston, Pascal Chanez, Mark Gjomarkaj, Peter H. Howarth, Ewa Niżankowska‐Mogilnicka, Roelinde Middelveld, Sven‐Erik Dahlén, Apostolos Bossios, Anna James, on behalf of the BIOAIR (Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease) and ChAMP consortia   +20 more
wiley   +1 more source

INDÚSTRIAS LÍTICAS DO SÍTIO REZENDE: PROCURA, CAPTAÇÃO, TRANSPORTE E USO DA MATÉRIA-PRIMA ENTRE GRUPOS DE AGRICULTORES CERAMISTAS.

Clio Arqueológica, 2007
Este artigo apresenta os dados referentes a procura, obtenção, transporte e uso de diferentes matérias-primas evidenciadas nas escavações do sítio Rezende, médio vale do Paranaíba, Minas Gerais.
Marcelo Fagundes
doaj