Results 41 to 50 of about 298,992 (250)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The right information may matter more than frequency-place alignment: Simulations of frequency-aligned and upward shifting cochlear implant processors for a shallow electrode array insertion [PDF]

, 2006
Objective: It has been claimed that speech recognition with a cochlear implant is dependent on the correct frequency alignment of analysis bands in the speech processor with characteristic frequencies (CFs) at electrode locations.
Faulkner, A, Norman, C, Rosen, S
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Smart binary phase‐coding for pulse‐compression radar: An electronic protection technique against repeater jamming

IET Wireless Sensor Systems
Nowadays, modern radar systems increase their target detection capabilities by processing pulses coherently. On the other hand, digital radio frequency memory‐based modern jammers have the ability to work coherently and can deceive radars even with a ...
Alper Yıldırım, Serkan Kiranyaz
doaj   +1 more source

On TDE techniques for the radar signal

The Journal of Engineering, 2019
The time-delay estimation (TDE) arises in many applications, especially in radar signal processing. In this study, different TDE techniques are considered based on well-known approaches such as classical matched filter, multiple signal classification ...
Hongcai Xin, Xia Bai, Juan Zhao, Bingzhao Li   +3 more
doaj   +1 more source

Near-Range Multipath Mitigation Methodology for Multistatic SAR Applications Using Matched-Adaptive Filters

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2022
This article presents a methodology based on matched-adaptive filters, which is used to mitigate the effect of near-range multipath in multistatic SAR systems and transponders.
Filip Rosu, Andrei Anghel, Silviu Ciochina, Remus Cacoveanu, Mihai Datcu   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Coherent detection method for maneuvering target with complex motions

The Journal of Engineering, 2019
In this study, a coherent detection method is proposed to solve the problems during the coherent integration (CI) process, including the range cell migration (RCM) and Doppler spread (DS) effects which are caused by the complex motions of the maneuvering
Zhi Sun, Xiaolong Li, Guolong Cui, Tianxian Zhang, Lingjiang Kong   +4 more
doaj   +1 more source

Low-complexity high-performance GFSK receiver with carrier frequency offset correction [PDF]

, 2004
This paper presents an implementation of a GFSK receiver based on matched filtering of a sequence of K successive bits. This enables improved detection and superior BER performance but requires 2K matched filters of considerable complexity.
Tibenderana, C., Weiss, S.
core   +1 more source