Results 81 to 90 of about 298,992 (250)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Doppler Compensation Techniques for M-Ary Sequence Spread Spectrum Signals Based on Correlation Cost Factors in Mobile Underwater Acoustic Communication

Journal of Marine Science and Engineering
Unlike terrestrial radio, the speed of sound in the ocean is relatively slow, which results in mobile underwater M-ary spread spectrum communication typically exhibiting significant and variable multipath effects along with strong Doppler effects ...
Yubo Han, Shuping Han, Heng Zhao, Yaohui Hu, Jingfeng Xu, Gang Yang   +5 more
doaj   +1 more source

QPSK-Modulation Modem Invariant to the Rotation of the Signal Constellation Plane

Electrical, Control and Communication Engineering, 2018
In order to increase the efficiency of dedicated frequency channels, i.e. to increase the specific data transfer rate, multipositional quadrature phase shift keying (QPSK, aka 4-PSK) should be used.
Sadchenko Andrey, Kushnirenko Oleg
doaj   +1 more source

Adaptive Filtering Enhances Information Transmission in Visual Cortex

, 2006
Sensory neuroscience seeks to understand how the brain encodes natural environments. However, neural coding has largely been studied using simplified stimuli.
A Kohn, AA Emondi, AB Saul, AL Fairhall, Andrei V. Kurgansky, BC Skottun, C Blakemore, D Chander, D Smyth, DG Albrecht, DJ Field, DJ Field, DL Ringach, DL Ruderman, DW Dong, EP Simoncelli, F Rieke, FE Theunissen, FE Theunissen, G Felsen, Hiroki Sugihara, I Ohzawa, JA Movshon, JD Victor, JJ Atick, Kenneth D. Miller, L Maffei, Michael P. Stryker, MJ Nolt, MJ Wainwright, MN Kvale, MP Sceniak, N Brenner, N Brenner, NC Rust, R Baddeley, R de Boer, R Shapley, RM Shapley, SA Baccus, Sergei P. Rebrik, SG Solomon, SM Smirnakis, SP Brown, SV David, T Hosoya, T Sharpee, Tatyana O. Sharpee, V Dragoi, Y Dan   +49 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Energy normalization of TV viewed optical correlation (automated correlation plane analyzer for an optical processor) [PDF]

An automatic correlation plane processor that can rapidly acquire, identify, and locate the autocorrelation outputs of a bank of multiple optical matched filters is described.
Grumet, A.
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source