Results 191 to 200 of about 664,357 (236)

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Specificity, Co-Occurrence, and Growth: Math and Reading Skill Development in Children With Learning Disabilities. [PDF]

J Learn Disabil
Connors KH, Guertin EL, Nichol M, Bosson-Heenan JM, Gruen JR, Frijters JC.   +5 more
europepmc   +1 more source

High-Energy-Density Aqueous Zinc-Ion Batteries: Recent Progress, Design Strategies, Challenges, and Perspectives. [PDF]

Adv Mater
Tang M, Liu Q, Zou X, Zhang B, An L.
europepmc   +1 more source

Strong Matching Preclusion

Theoretical Computer Science, 2011
The matching preclusion problem, introduced by Brigham et al. [R.C. Brigham, F. Harary, E.C. Violin, and J. Yellen, Perfect-matching preclusion, Congressus Numerantium 174 (2005) 185–192], studies how to effectively make a graph have neither perfect ...
Jung-Heum Park, Insung Ihm
exaly   +4 more sources

Conditional Matching Preclusion for Folded Hypercubes

Journal of Interconnection Networks, 2019
Let G be a graph with an even number of vertices. The matching preclusion number of G is the minimum number of edges whose deletion leaves the resulting graph without a perfect matching, and the conditional matching preclusion number of G is the minimum number of edges whose deletion results in a graph with no isolated vertices and without a perfect ...
Heping Zhang, Ruizhi Lin
exaly   +4 more sources

Matching Preclusion and Conditional Matching Preclusion for Regular Interconnection Networks

Discrete Applied Mathematics, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
László Lipták, Eddie Cheng
exaly   +2 more sources

Matching Preclusion and Conditional Matching Preclusion Problems for the Folded Petersen Cube

Theoretical Computer Science, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Eddie Cheng
exaly   +4 more sources